Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P04637 (
p53
)
77,613
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The
tumor suppressor protein p53
is specifically expressed during meiosis in spermatocytes. Subsets of
p53
knockout mice exhibit testicular giant cell degenerative syndrome, which suggests
p53
may be associated with meiotic cell cycle and/or DNA metabolism. Here, we show that
p53
binds to the mouse
meiosis-specific RecA-like protein
Mus musculus DMC1 (MmDMC1). The C-terminal domain (amino acid 234-340) of MmDMC1 binds to DNA-binding domain of
p53 protein
.
p53
might be involved in homologous recombination and/or checkpoint function by directly binding to DMC1 protein to repress genomic instability in meiotic germ cells.
...
PMID:p53 Protein interacts specifically with the meiosis-specific mammalian RecA-like protein DMC1 in meiosis. 1476 57
