Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P04637 (
p53
)
77,613
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Genome-wide sequencing studies in breast cancer have recently identified frequent mutations in the
zinc finger protein 668
(
ZNF668
), the function of which is undefined. Here, we report that
ZNF668
is a nucleolar protein that physically interacts with and regulates
p53
and its negative regulator MDM2. Through MDM2 binding,
ZNF668
regulated autoubiquitination of MDM2 and its ability to mediate
p53
ubiquitination and degradation.
ZNF668
deficiency also impaired DNA damage-induced stabilization of
p53
. RNA interference-mediated knockdown of
ZNF668
was sufficient to transform normal mammary epithelial cells.
ZNF668
effectively suppressed breast cancer cell proliferation in vitro and tumorigenicity in vivo. Taken together, our studies identify
ZNF668
as a novel breast tumor suppressor gene that functions in regulating
p53
stability.
...
PMID:ZNF668 functions as a tumor suppressor by regulating p53 stability and function in breast cancer. 2185 83
