Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P04637 (
p53
)
77,613
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
p53
is a major cellular tumor suppressor that in addition to its nuclear, transcription-dependent activity is also known to function extranuclearly. Cellular stressors such as reactive oxygen species can promote translocation of
p53
into mitochondria where it acts to protect mitochondrial genome or trigger cell death via transcription-independent manner. Here we report that the mammalian homologue of yeast mitochondrial Afg1 ATPase (
LACE1
) promotes translocation of
p53
into mitochondria. We further show that
LACE1
exhibits significant pro-apoptotic activity, which is dependent on
p53
, and that the protein is required for normal mitochondrial respiratory function.
LACE1
physically interacts with
p53
and is necessary for mitomycin c-induced translocation of
p53
into mitochondria. Conversely, increased expression of
LACE1
partitions
p53
to mitochondria, causes reduction in nuclear
p53
content and induces apoptosis. Thus,
LACE1
mediates mitochondrial translocation of
p53
and its transcription-independent apoptosis.
...
PMID:LACE1 interacts with p53 and mediates its mitochondrial translocation and apoptosis. 2732 8
