Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P04637 (
p53
)
77,613
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We used DNA microarray screening to identify Ckap2 (
cytoskeleton associated protein 2
) as a novel p53 target gene in a mouse erythroleukemia cell line. DNA damage induces human and mouse CKAP2 expression in a
p53
-dependent manner and
p53
activates the Ckap2 promoter. Overexpressed Ckap2 colocalizes with and stabilizes microtubules. In
p53
-null cells, overexpression of Ckap2 induces tetraploidy with aberrant centrosome numbers, suggesting disturbed mitosis and cytokinesis. In
p53
-competent cells, Ckap2 does not induce tetraploidy but activates
p53
-mediated cell cycle arrest and apoptosis. Our data suggest the existence of a functional positive feedback loop in which Ckap2 activates the G1 tetraploidy checkpoint and prevents aneuploidy.
...
PMID:Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner. 1606 49
