Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P04637 (
p53
)
77,613
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
p53
has a crucial role in governing cellular mechanisms in response to a broad range of genotoxic stresses. During DNA damage,
p53
can either promote cell survival by activating senescence or cell-cycle arrest and DNA repair to maintain genomic integrity for cell survival or direct cells to undergo apoptosis to eliminate extensively damaged cells. The ability of
p53
to execute these two opposing cell fates depends on distinct signaling pathways downstream of
p53
. In this study, we showed that under DNA damage conditions induced by chemotherapeutic drugs, gamma irradiation and hydrogen peroxide,
p53
upregulates a novel protein,
proline-rich acidic protein 1
(
PRAP1
). We identified functional
p53
-response elements within intron 1 of
PRAP1
gene and showed that these regions interact directly with
p53
using ChIP assays, indicating that
PRAP1
is a novel p53 target gene. The induction of
PRAP1
expression by
p53
may promote resistance of cancer cells to chemotherapeutic drugs such as 5-fluorouracil (5-FU), as knockdown of
PRAP1
increases apoptosis in cancer cells after 5-FU treatment.
PRAP1
appears to protect cells from apoptosis by inducing cell-cycle arrest, suggesting that the induction of
PRAP1
expression by
p53
in response to DNA-damaging agents contributes to cancer cell survival. Our findings provide a greater insight into the mechanisms underlying the pro-survival role of
p53
in response to cytotoxic treatments.
...
PMID:PRAP1 is a novel executor of p53-dependent mechanisms in cell survival after DNA damage. 2323 59
