Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P04637 (
p53
)
77,613
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
An integrated, virtual database screening strategy has led to 7-[anilino(phenyl)methyl]-
2-methyl-8-quinolinol
(4, NSC 66811) as a novel inhibitor of the murine double minute 2 (MDM2)-
p53
interaction. This quinolinol binds to MDM2 with a Ki of 120 nM and activates
p53
in cancer cells with a mechanism of action consistent with targeting the MDM2-
p53
interaction. It mimics three
p53
residues critical in the binding to MDM2 and represents a promising new class of non-peptide inhibitors of the MDM2-
p53
interaction.
...
PMID:Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy. 1678 31
