Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P04637 (
p53
)
77,613
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Temozolomide (TMZ) resistance is a complication of treatment of glioma, and new strategies are urgently required to overcome chemoresistance in glioma cells. In the present study, it was demonstrated that
tripartite motif-containing 31
(
TRIM31
) was abnormally upregulated in glioma tissues and cell lines compared with normal samples. Furthermore, the role of
TRIM31
was assessed by overexpressing and knocking down its expression. Overexpression of
TRIM31
increased cell viability, increased TMZ IC
50
values and inhibited apoptosis in A172 and U251 cells; whereas overexpression of
TRIM31
decreased the expression of the apoptosis-associated
protein p53
. Knockdown of
TRIM31
increased apoptosis in cells treated with TMZ. Additionally, the mechanisms by which
TRIM31
affected glioma cells treated with TMZ were determined. Overexpression of
TRIM31
increased phosphorylation of AKT and inhibiting the PI3K/AKT signaling pathway abolished the increase in cell viability and decreased phospho-Akt protein expression in
TRIM31
overexpressing A172 cells treated with TMZ. Together, the findings suggest that
TRIM31
may be a potentially novel target for glioma chemotherapy.
...
PMID:TRIM31 enhances chemoresistance in glioblastoma through activation of the PI3K/Akt signaling pathway. 3276 50
