Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P04637 (
p53
)
77,613
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The
tumor suppressor p53
has critical roles in regulating lipid metabolism, but whether and how
p53
regulates cardiolipin (CL) de novo biosynthesis is unknown. Here, we report that
p53
physically interacts with histone deacetylase SIRT6 in vitro and in vivo, and this interaction increases following palmitic acid (PA) treatment. In response to PA,
p53
and SIRT6 localize to chromatin in a
p53
-dependent manner. Chromatin
p53
and SIRT6 bind the promoters of
CDP-diacylglycerol synthase 1
and 2 (CDS1 and CDS2), two enzymes required to catalyze CL de novo biosynthesis. Here, SIRT6 serves as a co-activator of
p53
and effectively recruits RNA polymerase II to the CDS1 and CDS2 promoters to enhance CL de novo biosynthesis. Our findings reveal a novel, cooperative model executed by
p53
and SIRT6 to maintain lipid homeostasis.
...
PMID:p53 cooperates with SIRT6 to regulate cardiolipin de novo biosynthesis. 3023 40
