Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P04637 (
p53
)
77,613
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The
tumor suppressor p53
has been proposed to bind target promoters upon genotoxic stress. However, recent evidence shows that
p53
occupies some target promoters without such stress, suggesting that a negative regulator might render
p53
transcriptionally inactive on these promoters. Here we show that
calcineurin binding protein 1
(Cabin1) is a negative regulator of
p53
. Downregulation of Cabin1 induces activation of a subset of p53 target genes. Cabin1 physically interacts with
p53
on these target promoters and represses
p53
transcriptional activity in the absence of genotoxic stress, by regulating histone modification and
p53
acetylation marks. Knockdown of Cabin1 retards cell growth and promotes cell death after DNA damage in a
p53
-dependent manner. Thus, Cabin1 inhibits
p53
function on chromatin in the quiescent state; the presence of inactive
p53
on some promoters might allow a prompt response upon DNA damage.
...
PMID:Cabin1 restrains p53 activity on chromatin. 1973 84
