Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P04637 (
p53
)
77,613
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Pilomyxoid astrocytoma
(
PMA
) is a newly identified variant of pilocytic astrocytoma (PA). We report three cases of
PMA
with comparison to seven cases of PA in terms of their clinicopathological features. The three cases occurred at the ages of 2, 36 and 6 years, and their tumors were located in the left basal ganglia, the pineal gland, and the cerebellum, respectively. They were diagnosed
PMA
by surgical specimens that showed a characteristic monomorphous architecture with an angiocentric growth pattern and myxoid background. One patient developed localized relapse at 6 months after the surgery, but the other patients remained alive without tumor progression more than 5 years after treatment. In analysis of the immunohistochemical association in
PMA
and PA, no specific staining was found to be useful for differential diagnosis of
PMA
from PA. The expression of biomarkers including O-6-methylguanine-DNA methyltransferase,
p53
, MIB-1, and EGF receptor neither distinguished
PMA
from PA nor correlated with outcome. But almost all
PMA
and PA that demonstrated prominent positivity for nestin showed a high MIB-1 labelling index (LI), and four of these five patients suffered a relapse in the early phase. These results suggest that immunohistochemical expression of nestin and MIB-1 LI may correlate with the aggressiveness of the tumor in PA and
PMA
.
...
PMID:Clinico-pathological feature of pilomyxoid astrocytomas: three case reports. 2066 8
