Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P04637 (
p53
)
77,613
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We identified and characterized two new ING family genes,
p29ING4
and p28ING5,coding for two proteins of 249 and 240 amino acids, respectively. Both
p29ING4
and p28ING5 proteins have a plant homeodomain finger motif also found in other ING proteins, and which is common in proteins involved in chromatin remodeling.
p29ING4
or p28ING5 overexpression resulted in a diminished colony-forming efficiency, a decreased cell population in S phase, and the induction of apoptosis in a
p53
-dependent manner. Both
p29ING4
and p28ING5 activate the p21/waf1 promoter, and induce p21/WAF1 expression.
p29ING4
and p28ING5 enhance
p53
acetylation at Lys-382 residues, and physically interact with p300, a member of histone acetyl transferase complexes, and
p53
in vivo. These results indicate that
p29ING4
and p28ING5 may be significant modulators of
p53
function.
...
PMID:p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. 1275 Feb 54
