Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P04637 (
p53
)
77,613
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In several types of solid tumours, circulating antibodies to
p53
are seen in about a third of cases with a
p53
mutation, but are absent in cases without
p53
mutation. Therefore detection of those antibodies has relatively low sensitivity but high specificity in the detection of
p53
mutations. We looked for circulating
p53
antibodies by ELISA in 56
adult non-Hodgkin's lymphoma
(NHL) and 80 multiple myeloma cases. A certain or highly probable
p53
mutation was found by SSCP analysis, immunocyto- or immunohistochemistry in 8/35 (23%) NHL cases and 2/19 (10%) MM cases analysed by these techniques. None of the 80 MM cases and only one of the 56 cases of NHL had circulating
p53
antibodies. The positive case had Burkitt's lymphoma and a
p53
missense mutation at codon 273. Thus, very few MM and NHL patients with a
p53
mutation develop
p53
antibodies and this test does not appear to be useful in haematological malignancies.
...
PMID:Very low incidence of p53 antibodies in adult non-Hodgkin's lymphoma and multiple myeloma. 945 Aug 8
