Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P04637 (
p53
)
77,613
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Calcifying odontogenic cyst
(
COC
) is a developmental odontogenic cyst in the jaw. Because of its diverse histopathologic features and biological behavior, there has long been confusion with regard to its nature as a cyst or neoplasm. This study evaluated the proliferative activity of 57
COC
samples, including simple cyst (10 cases), cystic neoplasm (34 cases), solid neoplasm (6 cases) and combined lesion (7 cases) by
p53
and PCNA immunohistochemical staining. For assessment of
p53
and PCNA positivity, the number of positively stained cells with brown-stained nuclei was counted in 1000 cells from each sample.
p53
and PCNA expression in the solid neoplasm subtype were significantly higher when compared to cystic neoplasm and simple cyst (P < 0.05). The lowest
p53
and PCNA expression was found in the simple cyst subtype.
p53
and PCNA expression in the basal and suprabasal layers was significantly higher in the solid subtype when compared to others, and the difference between
COC
groups was significant. The results demonstrated that within benign types of
COC
, the amount of
p53
and PCNA in proliferative epithelium is significantly higher when compared to non-proliferative epithelium.
p53
and PCNA markers are possible parameters for differentiation of
COC
subtypes.
...
PMID:Immunohistochemical analysis of p53 and PCNA expression in calcifying odontogenic cyst. 2120 64
