Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P04637 (p53)
 77,613 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Suppressor oncogene p53 is expressed more frequently in the nodular portion than the superficial spreading portion of the same melanoma. PCNA expression follows the same pattern but it is strongly expressed already in the superficial spreading portion. CD34 is found to label dermatofibrosarcoma protuberans. There is the mixture of negative strands but the immunostains are predominantly positive in the three cases studied. Neurogenic tumors are reactive but the intensity of staining is only moderate. Fibrous histiocytoma, dermatofibroma and other fibrohistiocytic tumors are non-reactive. CD34 is expressed in the outer root sheath of hair follicle below the sebaceous gland level. A case of piloepidermal cyst is CD34 positive. CD34 is expressed in vascular endothelial cells; not only hemangiomas but also lymphangiosarcoma is CD34 positive. A case of indeterminate cell histiocytosis following scabies and superficial variant of clear cell sarcoma are discussed as examples of new entities.
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PMID:Current topics of immunohistochemistry as applied to skin tumors. 769 83

Benign fibrous histiocytoma of the trachea is a rare neoplasm. We reported 2 cases, one aged 3 years and one 5 years, with endotracheal fibrous histiocytoma showing no clinical evidence of malignancy. Two segments of the trachea were resected and an end-to-end anastomosis was done in 1 case and circular resection of the left bronchi and carinoplasty for the other. Pathologically, both tumors consisted of spindle cells arranged in storiform and fascicular patterns. Immunohistochemically, tumor cells stained for vimentin and CD68 but were negative for P53. These cellular features and immunohistochemical findings indicate benign fibrous histiocytoma of the trachea. No recurrence was seen.
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PMID:Benign fibrous histiocytoma of the trachea. 1247 73