Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P04637 (p53)
 77,613 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In order to study the relationship of p53 gene mutation with the occurrence and prognosis of cancer of small intestine, expression of p53 protein was examined. The results showed that p53 protein expression was high in 75% of small intestine cancer, and 21.1% positive in tissues close to cancer. In 7 cases of small intestinal adenoma only one was positive. Sixteen cases of normal tissue of intestine showed negative expression of p53 protein. The study also found that the degree of p53 protein expression was significantly correlated with the degree of tumor cell differention, invasion, metastasis and prognosis.
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PMID:[Study of p53 protein expression in cancers of small intestine and its relationship to clinical course and prognosis]. 938 21

Aristolochic acid (AA) is a bioactive component of Chinese herbs, dietary supplements, slimming pills and contaminated flour, which is known to induce chronic tubulointerstitial disease. AA is also shown to be involved in the genesis of the upper urinary tract urothelial carcinoma (UTUC) and some other cancers, but its tumorigenic role is far to be understood. We performed a systematic literature review regarding the involvement of AA in malignant processes and molecular pathways of carcinogenesis. Twenty representative papers were selected for this review. These papers reveal that AA exposure increases the risk for UTUC, renal cell carcinoma, hepatocellular carcinoma, gastric and small intestine cancer. The role of AA in lymphomagenesis is also proposed. The A:T to T:A transversions occurring in the 5'-CpApG-3' trinucleotide context of the TP53 gene is considered to be the signature mutation of AA. Genes including H-ras, FGFR3, N-ras and BRCA2 are also involved. For further understanding of AA's role in tumorigenesis, the exploration of the AA's molecular signature is necessary.
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PMID:A systematic review of the possible carcinogenic role of the aristolochic acid. 2852 96