Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P04626 (erbB-2)
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Human Gene/Protein
tumor necrosis factor (ligand) superfamily, member 12 12.6
SNX1A 12.6
erbB-2 12.6
c-erbB-3 12.2
erbB-3 11.6
Sp2 transcription factor 11.6
Opioid binding protein/cell adhesion molecule-like 11.6
apoptosis repressor with CARD domain 11.0
p185 10.9
mutant p53 tumor suppressor 10.8
CBE1 10.6
amplified in osteosarcoma 10.6
herstatin 10.6
ERBB3 protein 10.6
Herstatin 10.5
MUC11 10.2
RING4 10.2
c-ros-1 10.2
CAB1 10.0
putative transmembrane receptor 10.0
NAPG 10.0
EGF receptor 9.9
NRG-4 9.8
neu 9.6
Eps15R 9.6
Ski oncoprotein 9.6
chemokine BRAK 9.6
COLM 9.6
TBC1D9 9.6
RABEP1 9.6
VPS37B 9.4
STARD10 9.4
NB3 9.4
VPS37C 9.4
MAGE2 9.2
Telethonin 9.1
Vascular endothelial growth factor D 9.1
rlf 9.1
GPR30 protein 9.0
focal adhesion kinase 1 9.0
p55c-fgr 9.0
NRG4 9.0
HRG4 9.0
HER4 8.9
Cyclin G-associated kinase 8.9
AKT2 protein 8.9
clathrin-associated protein 8.9
Br3 8.8
Calpain-2 8.8
phospholipase C-gamma 1 8.7
ErbB-3 8.7
NR6 8.7
betacellulin 8.7
B3-1 8.7
POB1 8.7
MED7 8.7
HRG 8.6
transforming growth factor-alpha 8.6
COPS3 8.6
SNX4 8.6
CD349 8.6
Transforming growth factor-alpha 8.6
hepatocellular carcinoma related protein 1 8.6
HSTF1 8.6
TOP2A protein 8.6
transforming growth factor alpha 8.5
UBTF 8.5
MXI 8.5
thyroid hormone receptor alpha 1 8.5
PINCH2 8.5
CITED4 8.5
GNN 8.5
eps15 8.4
neuregulin 8.4
STK1 8.3
tumor-related protein 8.3
lipophilin B 8.3
epidermal growth factor 8.3
HLC-1 8.2
Transforming growth factor alpha 8.2
NCL 8.2
heparin-binding EGF-like growth factor 8.2
Freud-1 8.2
Ymer 8.2
MIB1 8.1
ribosomal protein L19 8.1
TGF-alpha 8.1
Fibroblast growth factor receptor 2 8.1
MAM3 8.1
17-beta-hydroxysteroid dehydrogenase 8.1
HE4 protein 8.1
Dishevelled-2 8.1
RHBDF2 8.0
Hepatocyte growth factor receptor 8.0
Amine oxidase 8.0
natriuretic peptide receptor B 8.0
CRIPTO 8.0
rasGAP 8.0
c-src tyrosine kinase 8.0
HER2 8.0
PDGF B chain 8.0
L-myc 7.9
ZETA 7.9
DIRAS3 7.9
NRG-2 7.9
p53-related protein kinase 7.9
OVCA1 7.9
Signal transducer and activator of transcription 4 7.9
TGZ 7.9
MLN64 7.8
Grb7 7.8
BACH 7.8
hepatocystin 7.8
EAP30 7.8
amphiregulin 7.8
TA1 7.8
UBPY 7.8
CD34 molecule 7.8
MHC class II-associated invariant chain 7.8
B2t 7.8
DOK1 7.8
growth factor receptor-bound protein 2 7.7
protein-serine/threonine kinase 7.7
HLA-2 7.7
PACSIN2 7.7
MAGE3 7.7
EMS1 7.7
VPS36 7.7
ITAC 7.7
CA15 7.6
RB-1 7.6
GRM6 7.6
CAK1 7.6
RSK4 7.6
EGFR protein 7.6
NEU 7.6
HER3 7.6
THH 7.6
CAB2 7.6
A431 7.5
growth factor receptor binding protein 7.5
EHD3 7.5
proto-oncogene 7.5
ACK1 7.5
MAGE-2 7.5
FM3 7.5
SHC 7.4
hnRNPH 7.4
HEI10 7.4
PINX1 7.4
MUC12 7.4
EGFR 7.4
tyrosine protein kinase 7.4
CHMP3 7.4
guanine nucleotide releasing factor 7.4
DB5 7.4
GCDFP-15 7.4
receptor protein kinase 7.4
PTPH1 7.4
HG3 7.4
more...
Disease
Basal cell carcinoma with sebaceous differentiation 12.6
Laryngeal papilloma 9.6
Malignant insulinoma 9.6
Psoriatic plaque 9.4
PanIN-1A 9.4
Paget's disease of the nipple 9.3
comedo carcinoma 9.2
Secretory carcinoma of the breast 9.1
stage IIB cervical cancer 9.1
MDD2 9.1
Small cell osteosarcoma 8.6
comedo 8.5
Gastric dysplasia 8.4
PanIN-1B 8.3
Salivary duct carcinoma 8.2
stage II NSCLC 8.0
PanIN-1 7.8
uterine carcinosarcoma 7.8
PanIN-3 7.7
stage IB cervical cancer 7.7
ductal carcinoma in situ 7.6
benign proliferative breast disease 7.6
DA4 7.6
cutaneous leiomyoma 7.5
infiltrating ductal carcinoma 7.5
Extramammary Paget's disease 7.4
stage III breast cancer 7.4
Endometrioid carcinoma 7.4
Liver mass 7.3
ductal carcinoma 7.3
Pleomorphic carcinoma 7.2
LCIS 7.2
erythroblastosis 7.1
ovarian tumors of low malignant potential 7.1
VIN III 7.1
PanIN-2 7.0
metaplastic carcinoma 7.0
Peritoneal metastases 7.0
metastatic endometrial cancer 6.9
stage D prostate cancer 6.9
bilateral cancer 6.9
benign ovarian cyst 6.9
stage II breast cancer 6.8
small cell carcinoma of the cervix 6.8
Hailey-Hailey disease 6.8
apocrine metaplasia 6.7
pediatric medulloblastoma 6.7
fallopian tube cancer 6.7
lobular carcinoma in situ 6.7
recurrent endometrial cancer 6.6
Precancerous lesions 6.6
bladder neoplasm 6.6
Medullary carcinoma 6.5
Ductal carcinoma 6.5
recurrent breast cancer 6.5
stage I NSCLC 6.5
Polycystic liver disease 6.5
Epithelial hyperplasia 6.4
Paget's disease of the vulva 6.4
mucinous carcinoma 6.4
breast fibroadenoma 6.2
papillary serous carcinoma 6.2
stage IIIA NSCLC 6.2
Microcystic adnexal carcinoma 6.2
GFD 6.2
Breast carcinoma 6.2
fibrocystic disease 6.2
carcinoma of the breast 6.1
extensive stage SCLC 6.0
mammary tumor 6.0
GIN 6.0
metastatic breast cancer 5.9
transitional cell carcinoma of the bladder 5.9
Meningeal carcinomatosis 5.9
Psammoma 5.9
Ullrich 5.9
in situ breast cancer 5.9
breast cancer 5.8
endocrine neoplasm 5.8
Endometrium 5.7
epithelial ovarian cancer 5.7
Endometrium 5.7
dermatofibrosarcoma 5.7
Placenta accreta 5.6
PanIN 5.6
bilateral breast cancer 5.6
Parotid gland 5.6
Clear cell sarcoma 5.5
carcinoma of the breast 5.5
Lymph node metastases 5.5
endometrial adenocarcinoma 5.4
MDI 5.4
clear cell sarcoma of the kidney 5.4
CEP 5.4
Dukes 5.3
Ductal 5.3
Ureteral obstruction 5.3
ovarian cancer 5.3
retroviral disease 5.3
salivary gland cancer 5.3
lobular breast carcinoma 5.2
endometrial cancer 5.2
erythroplakia 5.2
Myoepithelial 5.2
TCC 5.2
malignant state 5.2
biliary tract cancer 5.2
CM1 5.2
inflammatory breast cancer 5.2
transitional cell carcinoma 5.1
carcinoma of the parotid 5.1
metastatic ovarian cancer 5.1
Papillary carcinoma 5.1
IRMA 5.1
HBT 5.1
large cell carcinomas 5.1
neoplastic transformation 5.0
carcinoma 5.0
adrenocortical cancer 5.0
carcinosarcoma 5.0
Sarcomatoid carcinoma 5.0
aggressiveness 5.0
epithelial tumor 5.0
invasive cancer 5.0
Chemoradiation 4.9
Esophageal adenocarcinoma 4.9
laryngeal squamous cell carcinoma 4.9
MCF 4.9
cervical dysplasia 4.9
fibrocystic breast disease 4.9
carcinoma in situ 4.9
Papilloma 4.8
BLM 4.8
bone marrow metastases 4.8
malignant pleural effusion 4.8
Recurrent disease 4.8
MEN 2B 4.7
FDC 4.7
adenocarcinoma of the stomach 4.7
leprechaunism 4.7
prostatic adenocarcinoma 4.7
stage IV NSCLC 4.7
keratoacanthoma 4.7
Carcinosarcoma 4.6
lung metastases 4.6
Fallopian tube 4.6
testicular seminoma 4.6
Adenoma 4.6
Adenoma 4.6
adenocarcinoma of the pancreas 4.6
adenocarcinoma of the lung 4.6
metastatic colon cancer 4.6
primary tumor 4.5
adenosis 4.5
Hyperplasia 4.5
squamous cell carcinoma of the penis 4.5
endometrial hyperplasia 4.5
premalignant condition 4.5
Lymph nodes 4.5
uterine cervix 4.5
more...
Symptom
female puberty 5.6
peri-menopausal 5.1
nipple discharge 4.5
rigors 4.5
nipple discharge 4.5
No adverse effect 4.2
chills 2.8
HSA 2.0
dry eye 1.2
asthenia 1.2
hoarseness 1.0
epigastric pain 0.8
syncope 0.4
Ill 0.1
cachexia 0.1
hepatomegaly 0.1
hemoptysis -0.0
erythema -0.1
starvation -0.5
chest pain -0.5
nausea and vomiting -0.7
nausea -1.0
cough -1.0
functional recovery -1.1
acidity -1.3
abdominal pain -1.4
headache -1.6
diarrhea -1.7
overweight -2.1
dyspnea -2.2
collapse -2.2
vomiting -2.4
pain -2.6
weakness -2.6
seizures -2.7
fatigue -3.1
anesthesia -3.2
Drug
Gris-PEG 9.4
CEA-Scan 9.2
Herceptin 8.7
Tykerb 7.8
Radicicol 7.5
Pertuzumab 7.1
Paraffin 6.8
Ontak 6.7
Ontak 6.7
Vandetanib 6.5
TMX 6.3
Ixabepilone 6.2
Gefitinib 6.2
Batimastat 6.0
Batimastat 6.0
Cetuximab 6.0
NOV 5.8
Compound 18 5.7
Celebrex 5.6
Taxotere 5.6
RBT 5.4
Chlorate 5.4
Arimidex 5.4
Zileuton 5.3
Xeloda 5.3
Emodin 5.3
Panitumumab 5.2
Navelbine 5.1
Emodin 5.0
Pefloxacin 4.9
Doyle 4.9
R-gene 4.9
Flavopiridol 4.9
Tarceva 4.8
Estriol 4.8
uPA 4.7
Gleevec 4.7
Docetaxel 4.6
CDX 4.6
Zoladex 4.5
Bayer 4.5
CER 4.5
Myricetin 4.3
Zoladex 4.3
Estrogens 4.2
CDX 4.1
Filgrastim 4.1
Erlotinib 4.0
Taxol 3.9
Olive oil 3.9
Filgrastim 3.9
Imatinib 3.9
MDM 3.9
Vinorelbine 3.8
Rosuvastatin 3.7
Angiotensin II 3.7
Retinoic acid 3.6
Luteinizing 3.5
ETS 3.5
Imiquimod 3.5
DM1 3.5
IFN-gamma 3.5
IL-11 3.4
Indocyanine green 3.4
BTC 3.4
ICI 3.3
Arsenic trioxide 3.2
Lovastatin 3.2
G418 3.0
Bortezomib 3.0
DNase I 2.9
Gelatin 2.8
Bevacizumab 2.8
ETA 2.7
Rituximab 2.7
IFN-beta 2.6
ADR 2.6
-deoxyadenosine 2.5
Doxycycline 2.5
ABC 2.5
CAM 2.4
TAT 2.3
Aloe 2.3
CCL 2.2
p75 2.2
Pronase 2.2
IL-2 2.2
MAP 2.1
Amiloride 2.0
Vitamin A 2.0
BH4 2.0
balanced salt solution 2.0
Allergen 2.0
G-CSF 1.8
Norplant 1.8
Amiloride 1.7
Gel 1.7
CPT-11 1.7
ACT 1.5
DHT 1.5
CSF 1.5
DHT 1.4
Adriamycin 1.4
Asn 1.4
L-tyrosine 1.4
Fraction 1.2
ROC 1.2
EE2 1.2
Forskolin 1.2
HCG 1.2
Growth hormone 1.0
Growth hormone 1.0
Vitamin E 0.9
CTX 0.8
HCH 0.8
Kenyan 0.8
lysine 0.7
PCB 0.5
CTX 0.1
vitamin E 0.1
Mutagen 0.0
ROS -0.1
PTH -0.2
NH3 -0.2
EPA -0.2
Dermatol -0.5
ENT -0.5
Monit -0.5
Ethanol -0.7
Leaf -0.8
NADH -0.9
TiO2 -0.9
Nephron -1.0
Nephron -1.6
Cardiovasc -3.0
Enzyme
cathepsin D 6.4
N-acetylglucosaminyltransferase III 6.0
rhomboid protease 5.8
PTPase 5.8
alpha-methylacyl-CoA racemase 5.7
ERK 5.7
CEP 5.6
phosphatidylinositol 4-kinase 5.5
CEP 5.3
N-acetylglucosaminyltransferase V 5.3
triose-phosphate isomerase 5.0
phosphatidylinositol-4,5-bisphosphate 3-kinase 4.9
thymidine phosphorylase 4.9
dihydrodiol dehydrogenase 4.8
phosphatidylinositol 3-kinase 4.7
farnesyltransferase 4.5
MEK 4.5
GRK2 4.4
protein farnesyltransferase 4.3
interstitial collagenase 4.3
topoisomerase 4.2
topoisomerase 4.2
mitogen-activated protein kinase 4.2
MMP-3 4.1
ricin 4.1
endoglycosidase H 4.1
phosphoinositide 3-kinase 4.0
prostaglandin synthetase 4.0
cytosine deaminase 4.0
farnesyltransferase 4.0
protein kinase C 4.0
prostate-specific antigen 3.9
HCS 3.9
endoproteinase Glu-C 3.8
phospholipase C 3.8
CGT 3.8
urokinase-type plasminogen activator 3.8
matrix metalloproteinase 2 3.7
STK11 3.7
protein kinase 3.6
diacylglycerol kinase 3.6
N-acetylglucosaminyltransferase 3.6
TGT 3.6
MMP 3.5
5alpha-reductase 3.5
5alpha-reductase 3.5
p80 3.5
matrix metalloproteinase 9 3.5
3-hydroxy-3-methylglutaryl-CoA reductase 3.4
PI-PLC 3.4
prostate-specific membrane antigen 3.4
thymidine kinase 3.3
heparinase 3.3
porphobilinogen deaminase 3.3
poly(A) polymerase 3.2
P-glycoprotein 3.2
mu-calpain 3.1
fatty acid desaturase 3.1
CD13 3.1
chloramphenicol acetyltransferase 3.1
S1 nuclease 3.1
insulin-degrading enzyme 3.0
enolase 3.0
ADH 3.0
PNGase F 3.0
caspase-2 3.0
MCS 3.0
peptidyl-prolyl cis-trans isomerase 3.0
microsomal epoxide hydrolase 2.9
dihydropyrimidine dehydrogenase 2.9
caspase-2 2.9
NOS 2.9
dihydrofolate reductase 2.9
cdc2 2.9
dipeptidyl peptidase IV 2.9
AMPK 2.8
phosphorylase kinase 2.8
phospholipase D 2.7
TdT 2.7
caspase-8 2.6
CD10 2.6
focal adhesion kinase 2.6
angiotensin-converting enzyme 2 2.6
glutathione S-transferase 2.6
neuropathy target esterase 2.5
glyceraldehyde-3-phosphate dehydrogenase 2.5
phosphoglycerate kinase 2.5
proprotein convertase 2.5
PDK1 2.4
GRK5 2.4
GSK 2.4
reverse transcriptase 2.4
15-lipoxygenase 2.4
TAT 2.3
dihydropyrimidine dehydrogenase 2.3
MAP 2.3
PARP 2.3
CaMKII 2.2
proteinase K 2.2
RNase H 2.1
cathepsin B 2.1
firefly luciferase 2.1
purine nucleoside phosphorylase 2.1
glyceraldehyde-3-phosphate dehydrogenase 2.1
glyceraldehyde-3-phosphate dehydrogenase 2.1
glucocerebrosidase 2.0
3-hydroxy-3-methylglutaryl coenzyme A reductase 2.0
MDR 2.0
APC 2.0
protein phosphatase 2A 2.0
glyceraldehyde-3-phosphate dehydrogenase 2.0
5'-nucleotidase 1.9
phospholipase A2 1.9
aryl hydrocarbon hydroxylase 1.9
DNA methyltransferase 1.9
caspase-3 1.8
luciferase 1.8
peroxidase 1.8
RNase 1.8
RNase 1.7
beta-galactosidase 1.7
cathepsin K 1.7
MEKK1 1.7
arginase 1.7
PAM 1.7
glyceraldehyde-3-phosphate dehydrogenase 1.7
caspase-9 1.7
NADPH oxidase 1.7
calcineurin 1.7
DNase 1.7
NADPH oxidase 1.6
cholesterol acyltransferase 1.6
alkaline phosphatase 1.5
ornithine decarboxylase 1.5
CYP3A4 1.5
guanylate cyclase 1.5
acid phosphatase 1.5
lipoxygenase 1.5
ribonuclease 1.5
ribonuclease 1.5
gamma-glutamyl transpeptidase 1.4
elastase 1.4
collagenase 1.4
proteasome 1.3
carbonic anhydrase 1.3
CDR 1.3
PKG 1.3
glutamine synthetase 1.3
hypoxanthine-guanine phosphoribosyltransferase 1.3
thrombin 1.2
endonuclease 1.2
sialidase 1.2
histone acetyltransferase 1.2
phosphorylase 1.1
tyrosine hydroxylase 1.0
alcohol dehydrogenase 1.0
isocitrate dehydrogenase 1.0
thyroid peroxidase 1.0
furin 0.9
aldose reductase 0.9
more...
Compound
4-quinolinecarbaldehyde 11.6
C2B5 11.0
4-quinolinecarbaldehyde 11.0
4-quinolinecarbaldehyde 10.6
3,4,5-trihydroxybenzaldehyde 10.2
Dianon 10.2
NHU 10.0
DABI 9.2
4-ethoxyphenol 9.1
Aeroplysinin-1 8.8
chlorocyclohexane 8.0
Solamargine 7.8
NEU 7.6
Tectorigenin 7.6
IDC 7.4
N-ethylurea 7.2
Azoxymethane 7.2
Kyotorphin 6.9
Herbimycin 6.8
1,2,3,4,5,6-hexachlorocyclohexane 6.7
1,2,3,4,5,6-hexachlorocyclohexane 6.6
Tuberin 6.4
FANFT 6.2
TMU 6.1
Cbl 6.1
Estramustine 6.0
Latrunculin B 5.9
BTL 5.9
BDH 5.8
TIF 5.7
Glucosylceramide 5.7
Chlorate 5.7
DFS 5.7
Phosphoserine 5.6
Geldanamycin 5.6
ENU 5.5
MBT 5.5
INT 5.4
TFF 5.4
SP-1 5.4
3-octanone 5.3
Chlorate 5.3
tyrosine 5.3
Emodin 5.2
EOC 5.2
Leflunomide 5.2
DCC 5.2
Tyrosine 5.1
Withaferin A 5.1
BTG 5.1
Tunicamycin 5.1
ethyl cyanoacetate 5.1
BTG 5.1
TCC 5.1
MDA 5.0
Tamoxifen 4.9
Anastrozole 4.9
DGE 4.9
DGE 4.9
DGE 4.9
quinazoline 4.9
quinazoline 4.9
Tamoxifen 4.9
R-gene 4.9
phosphoserine 4.8
11,12-EET 4.8
1,1,2-trichloroethane 4.7
delta-HCH 4.7
DBI 4.7
(-)-Epigallocatechin 4.7
cyclohexanecarboxamide 4.7
Rottlerin 4.7
Rottlerin 4.6
Rottlerin 4.5
Capecitabine 4.5
o,p'-DDT 4.5
Phosphatidylinositol 4.5
Emodin 4.5
BSH 4.5
HBr 4.5
AF-2 4.5
LY 294002 4.4
Carcinogen 4.4
Hypericin 4.4
4-methylphenyl 4.4
Estriol 4.4
TEP 4.3
AIB 4.3
malononitrile 4.3
Arsenite 4.3
2,4,5-T 4.3
DMC 4.3
TNM 4.2
20-HETE 4.2
Keratin 4.2
T 1 4.2
Estrogen 4.1
Thymidine 4.1
MEK 4.1
Genistein 4.1
BOP 4.1
Daidzein 4.1
Tiron 4.1
Gliotoxin 4.1
Ang II 4.1
HBB 4.0
TPA 4.0
Estrogen 4.0
N-(4-hydroxyphenyl)retinamide 4.0
alpha-HCH 4.0
1-hexene 4.0
Wortmannin 4.0
K19 4.0
Uridine 3.9
BzATP 3.9
TCDD 3.9
VLA 3.9
TGT 3.9
GAP 3.9
Norton 3.8
Okadaic acid 3.8
TPA 3.8
Poly(I:C) 3.8
GM3 3.8
HCP 3.8
1,2-dimethylhydrazine 3.8
Selectin 3.8
Docetaxel 3.7
MIA 3.7
malonyl-CoA 3.7
Celecoxib 3.7
DPN 3.6
BUdR 3.6
Phorbol 3.6
H-3 3.5
Conjugated linoleic acid 3.5
HCP 3.5
MTA 3.5
Glu-Glu 3.4
Staurosporine 3.4
Biotin 3.4
APH 3.4
OPE 3.4
DMPC 3.4
PGJ2 3.4
threonine 3.4
Staurosporine 3.4
SPF 3.4
2,4-dichlorophenyl 3.3
2,4-dichlorophenyl 3.3
BTC 3.3
Isoform 3.3
carbonic acid 3.3
carbonic acid 3.3
carbonic acid 3.3
DBD 3.3
carbonic acid 3.3
carbonic acid 3.3
carbonic acid 3.3
carbonic acid 3.3
more...