Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P04626 (erbB-2)
 5,251 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
erbB-2 5251
epidermal growth factor 1147
EGF receptor 991
p53 745
HER2 517
epidermal growth factor receptor 510
neu 497
tyrosine kinase 478
EGFR 392
Mol 391
Sep 340
estrogen receptor 317
progesterone receptor 260
proto-oncogene 243
c-myc 184
Ki-67 180
A431 174
ras 165
p185 158
EGF 139
receptor tyrosine kinase 130
nodal 124
proliferating cell nuclear antigen 115
bcl-2 115
neuregulin 108
transforming growth factor-alpha 88
transforming growth factor alpha 79
p21 75
oestrogen receptor 72
Bcl-2 71
ERK1 71
glycoprotein 71
insulin 70
hormone receptor 69
ATP 67
cathepsin D 66
extracellular signal-regulated kinase 64
threonine 63
ERK 62
collagen 62
K-ras 61
c-erbB-3 60
platelet-derived growth factor 60
MAPK 60
E-cadherin 58
erbB-3 58
cyclin D1 57
tyrosine kinase receptor 55
cytokeratin 55
TGF-alpha 54
polypeptide 54
vascular endothelial growth factor 53
MIB 53
IFN-gamma 53
cytokine 51
H-ras 49
phosphatidylinositol 3-kinase 49
vimentin 48
c-fos 48
MAP kinase 46
MEK 45
CEA 44
mitogen-activated protein 43
BRCA1 42
CD8 42
amphiregulin 42
HLA-A2 41
c-Src 40
matrix metalloproteinase 40
fused 40
mutant p53 39
p38 38
protein tyrosine kinase 38
heparin-binding EGF-like growth factor 38
ERBB2 37
AKT 36
beta-catenin 35
transmembrane protein 32
p27 32
carcinoembryonic antigen 32
androgen receptor 32
endoplasmic reticulum 32
peroxidase 32
VEGF 31
kit 31
tumor necrosis factor 31
phosphatase 30
pS2 30
FISH 29
angiotensin II 29
HLA 29
receptor kinase 29
p16 29
scFv 28
membrane-bound 28
CD4 28
mucin 28
NDF 27
fibronectin 27
insulin receptor 27
adaptor protein 27
transmembrane glycoprotein 27
HER4 26
IFN 26
c-Ha-ras 25
TNM 25
insulin-like growth factor 25
tumour suppressor 24
HER3 24
MIB1 24
cyclooxygenase-2 24
interferon 24
PTEN 23
G protein-coupled receptor 23
Ang II 23
MMP-9 23
alkaline phosphatase 23
interferon-gamma 23
caspase-3 23
BRCA2 22
GTP 22
COX-2 22
IL-2 22
TGF-beta 22
PI3K 22
platelet-derived growth factor receptor 22
transferrin receptor 22
NCL 21
p42 21
PLC 21
MUC1 21
protein-tyrosine kinase 21
P-glycoprotein 20
urokinase-type plasminogen activator 20
nm23 20
CD31 20
Raf-1 20
Epidermal growth factor receptor 20
betacellulin 20
aromatase 20
c-Jun 19
c-kit 19
MHC class I 19
metalloproteinase 19
p85 19
catenin 19
lymphoid 19
telomeric 19
hepatocyte growth factor 19
transmembrane receptor 19
nerve growth factor 19
MDM2 19
membrane protein 18
osteosarcoma 18
p44 18
cage 18
protein kinase B 18
MMP-2 18
beta 1 18
cyclin 17
more...
Disease
tumor 1917
cancer 1894
breast cancer 1507
carcinoma 830
metastases 339
adenocarcinoma 210
carcinogenesis 209
ovarian cancer 184
squamous cell carcinoma 151
tumorigenesis 138
MCF 138
tumor growth 130
ductal carcinoma in situ 125
tumor progression 114
epithelial ovarian cancer 101
gastric cancer 99
ductal carcinoma 94
lung cancer 92
prostate cancer 85
metastatic breast cancer 79
primary tumor 78
endometrial cancer 70
mammary tumor 69
aggressiveness 64
bladder cancer 58
non-small cell lung cancer 55
pancreatic cancer 51
colorectal cancer 49
melanoma 43
dysplasia 43
adenoma 42
lung carcinoma 37
hepatocellular carcinoma 32
comedo 32
carcinoma of the breast 32
aggression 30
cervical cancer 30
carcinoma in situ 29
glioma 28
leukemia 27
neoplastic transformation 27
colon cancer 26
glioblastoma 26
retinoblastoma 24
pertussis 23
infiltrating ductal carcinoma 23
transitional cell carcinoma 23
lung metastases 22
PDB 22
renal cell carcinoma 21
osteosarcoma 19
SCID 19
liver metastases 19
uterine cervix 18
Barrett's esophagus 17
erythroblastosis 17
Dukes 16
invasive cancer 16
small cell lung cancer 16
carcinoma of the breast 16
tumor angiogenesis 14
sarcoma 14
BLM 14
mucinous carcinoma 13
herpes simplex 12
residual disease 12
recurrent breast cancer 12
endometrial adenocarcinoma 12
esophageal cancer 12
chronic pancreatitis 12
uterus 12
papilloma 11
esophageal cancer 11
APC 11
hypertension 11
carcinosarcoma 11
cirrhosis 11
multiple myeloma 11
solid tumor 11
chronic myeloid leukemia 11
neuroblastoma 11
prostatic adenocarcinoma 11
epithelial tumor 10
transitional cell carcinoma of the bladder 10
lymphoma 10
Blocking 10
asthma 10
EMA 9
Paget's disease of the nipple 9
pheochromocytoma 9
lobular carcinoma in situ 9
idiopathic dilated cardiomyopathy 9
hepatoblastoma 8
diabetes 8
oral cancer 8
cold 8
PIN 8
trisomy 8
PSA 8
cholera 8
ischemia 8
ATM 8
obesity 8
infectious diseases 7
head and neck cancer 7
SDS 7
brain tumor 7
Hailey-Hailey disease 7
rhabdomyosarcoma 7
vagina 7
glioblastoma multiforme 7
cervical intraepithelial neoplasia 7
basal cell carcinoma 7
EIA 7
Epstein 6
liver cancer 6
suicide 6
acute promyelocytic leukemia 6
endometrial hyperplasia 6
MDI 6
CEP 6
meningioma 6
fibrocystic disease 6
psoriasis 6
tumor initiation 6
schizophrenia 6
adenocarcinoma of the lung 6
tetanus 6
vaccinia 6
atherosclerosis 6
cystic fibrosis 6
medulloblastoma 6
B-cell lymphoma 6
Salivary duct carcinoma 6
thyroid cancer 6
human papilloma virus 5
human papilloma virus 5
WT1 5
heart failure 5
immunodeficiency 5
DDP 5
minimal residual disease 5
Pancreas 5
liver cancer 5
neoplastic process 5
brain metastases 5
bone metastases 5
virus infection 5
Dissociation 5
fibrosarcoma 5
Rous sarcoma 5
hepatitis C 5
Leukemia 5
hepatitis B 5
uterine carcinosarcoma 5
stage I NSCLC 5
cytomegalovirus 5
gestational trophoblastic disease 5
astrocytoma 5
TCC 5
more...
Symptom
pain 7
chills 5
starvation 3
headache 3
rigors 3
diarrhea 3
erythema 2
HSA 2
Ill 2
nipple discharge 2
cough 2
seizures 2
anesthesia 2
abdominal pain 2
syncope 2
nipple discharge 2
chest pain 2
nausea 2
cachexia 1
No adverse effect 1
female puberty 1
nausea and vomiting 1
dry eye 1
weakness 1
vomiting 1
functional recovery 1
asthenia 1
hepatomegaly 1
peri-menopausal 1
epigastric pain 1
dyspnea 1
fatigue 1
hoarseness 1
collapse 1
overweight 1
hemoptysis 1
acidity 1
Drug
Herceptin 152
IFN-gamma 53
Paraffin 39
Dermatol 31
IL-2 22
lysine 16
CSF 14
Gefitinib 14
Angiotensin II 11
MAP 11
DNase I 10
Cetuximab 10
ICI 9
uPA 9
ABC 8
Taxol 8
Gel 8
Docetaxel 7
Retinoic acid 7
Estrogens 7
Bayer 6
Gleevec 6
Imatinib 6
ETS 5
Asn 5
Taxotere 5
CAM 5
Cardiovasc 4
Monit 4
ROC 3
ETA 3
Pertuzumab 3
CTX 3
Rituximab 3
EE2 3
DM1 3
Emodin 3
ROS 3
Emodin 3
p75 3
vitamin E 3
IFN-beta 3
G418 3
G-CSF 3
NADH 2
Tykerb 2
Erlotinib 2
Bevacizumab 2
Doyle 2
Adriamycin 2
Leaf 2
Radicicol 2
Vitamin A 2
Vandetanib 2
IL-11 2
ADR 2
Gelatin 2
Lovastatin 2
NOV 2
Arsenic trioxide 2
Luteinizing 2
-deoxyadenosine 2
Bortezomib 2
TAT 2
Celebrex 1
Filgrastim 1
Nephron 1
BTC 1
TiO2 1
Estriol 1
Flavopiridol 1
Zileuton 1
Filgrastim 1
DHT 1
TMX 1
BH4 1
Chlorate 1
Allergen 1
Pronase 1
CER 1
L-tyrosine 1
balanced salt solution 1
Nephron 1
ENT 1
Batimastat 1
Arimidex 1
RBT 1
Ethanol 1
Batimastat 1
CCL 1
Rosuvastatin 1
Aloe 1
Ontak 1
R-gene 1
Gris-PEG 1
MDM 1
Vinorelbine 1
Norplant 1
Myricetin 1
CDX 1
Ixabepilone 1
Pefloxacin 1
NH3 1
CDX 1
Indocyanine green 1
Amiloride 1
CTX 1
CEA-Scan 1
ACT 1
Doxycycline 1
PCB 1
Vitamin E 1
Kenyan 1
Imiquimod 1
Mutagen 1
Growth hormone 1
Zoladex 1
Panitumumab 1
Olive oil 1
Xeloda 1
Fraction 1
Ontak 1
DHT 1
PTH 1
EPA 1
Amiloride 1
Zoladex 1
HCH 1
Forskolin 1
Navelbine 1
Growth hormone 1
Compound 18 1
CPT-11 1
HCG 1
Tarceva 1
Enzyme
ERK 814
mitogen-activated protein kinase 282
protein kinase 168
protein kinase C 129
MEK 66
cathepsin D 58
phosphatidylinositol 3-kinase 49
focal adhesion kinase 44
phospholipase C 43
peroxidase 37
topoisomerase 30
reverse transcriptase 28
topoisomerase 27
urokinase-type plasminogen activator 24
alkaline phosphatase 23
luciferase 22
glutathione S-transferase 22
caspase-3 21
P-glycoprotein 20
prostate-specific antigen 17
phosphoinositide 3-kinase 16
AMPK 14
thrombin 13
thymidine kinase 12
catalase 12
proteasome 12
APC 11
PARP 11
RNase 10
cdc2 10
trypsin 10
CD10 10
MMP-3 10
PTPase 9
RNase 9
calcineurin 9
NOS 9
ricin 9
phospholipase A2 9
beta-galactosidase 8
MMP 8
collagenase 8
caspase-8 7
dihydrofolate reductase 7
CEP 7
endonuclease 7
chloramphenicol acetyltransferase 7
lactate dehydrogenase 6
GSK 6
NADPH oxidase 6
acid phosphatase 6
MAP 6
CEP 6
RNA polymerase 6
glyceraldehyde-3-phosphate dehydrogenase 6
superoxide dismutase 6
tyrosine hydroxylase 5
CD13 5
thymidine phosphorylase 5
S1 nuclease 5
enolase 5
prostaglandin synthetase 5
matrix metalloproteinase 2 5
endoglycosidase H 5
ATPase 5
phosphatidylinositol 4-kinase 5
NADPH oxidase 5
farnesyltransferase 4
caspase-9 4
guanylate cyclase 4
phospholipase D 4
matrix metalloproteinase 9 4
elastase 4
gamma-glutamyl transpeptidase 4
DNase 4
lipoxygenase 4
farnesyltransferase 4
CYP3A4 3
ACS 3
adenylate cyclase 3
lysozyme 3
carbonic anhydrase 3
glyceraldehyde-3-phosphate dehydrogenase 3
tissue plasminogen activator 3
prostate-specific membrane antigen 3
proteinase K 3
glyceraldehyde-3-phosphate dehydrogenase 3
interstitial collagenase 3
glyceraldehyde-3-phosphate dehydrogenase 3
alcohol dehydrogenase 3
glyceraldehyde-3-phosphate dehydrogenase 3
ribonuclease 3
DNA methyltransferase 3
MDR 3
cathepsin B 3
ornithine decarboxylase 3
NO synthase 3
ribonuclease 3
GRK2 3
ADH 3
CaMKII 3
glutamine synthetase 2
DNA polymerase 2
PDK1 2
5'-nucleotidase 2
protein phosphatase 2A 2
PNGase F 2
3-hydroxy-3-methylglutaryl-CoA reductase 2
renin 2
dipeptidyl peptidase IV 2
phosphoglycerate kinase 2
arginase 2
phosphodiesterase 2
firefly luciferase 2
RNase H 2
tyrosinase 2
5alpha-reductase 2
phosphorylase 2
cytosine deaminase 2
TAT 2
ACE 2
xanthine oxidase 2
5alpha-reductase 2
heparinase 2
TdT 2
diacylglycerol kinase 2
chymotrypsin 2
transcriptase 2
rhomboid protease 1
phosphorylase kinase 1
thymidylate synthase 1
cholesterol acyltransferase 1
dihydropyrimidine dehydrogenase 1
demethylase 1
aryl hydrocarbon hydroxylase 1
MEKK1 1
neuraminidase 1
protein farnesyltransferase 1
caspase-2 1
porphobilinogen deaminase 1
thromboplastin 1
histone acetyltransferase 1
PAM 1
urease 1
proprotein convertase 1
fatty acid desaturase 1
subtilisin 1
cellulase 1
HSD 1
complex I 1
p80 1
STK11 1
dihydropyrimidine dehydrogenase 1
plasmin 1
thyroid peroxidase 1
furin 1
dihydrodiol dehydrogenase 1
glutathione peroxidase 1
15-lipoxygenase 1
phosphatidylinositol-4,5-bisphosphate 3-kinase 1
more...
Compound
DNA 730
tyrosine 615
Dec 384
Clin 300
MDA 128
calcium 96
threonine 75
acetate 72
ATP 67
phosphate 66
serine 60
sodium 42
methionine 40
cAMP 38
MEK 37
retinoic acid 35
Phe 32
oxygen 30
Estrogen 28
Estrogen 28
alanine 28
leucine 27
water 26
formaldehyde 26
arginine 25
TNM 25
lysine 24
GTP 23
glucose 22
MTT 22
Tyrosine 22
sulfate 20
cysteine 20
Cbl 20
Ang II 19
Triton X-100 19
pyrimidine 18
Tamoxifen 18
COS 18
Tamoxifen 18
pyrimidine 18
silver 15
ADP 15
Asp 15
ADP 15
hydrogen 15
ADP 15
NH2 14
DCC 14
TPA 13
TPA 13
H2O2 13
glutamic acid 12
Pac 12
phosphoserine 12
manganese 11
Insulin 11
Angiotensin II 11
iron 11
DFS 11
valine 11
Gly 11
PEG 11
Ile 11
iodine 11
bromide 10
salt 10
TNF 10
Phosphatidylinositol 10
quinazoline 9
ICI 9
AMP 9
proline 9
quinazoline 9
IDC 9
CAM 8
urea 8
galactose 8
nitrogen 8
His 8
dUTP 8
zinc 8
glutamate 8
nitric oxide 7
PMA 7
GDP 7
pyrene 7
PGE 7
DDP 7
N-acetylcysteine 7
SDS 7
tryptophan 7
ENU 6
Mg2+ 6
Adriamycin 6
Triton 6
INT 6
vitamin D 6
MAP 6
Estradiol 6
Genistein 6
ADR 6
Progesterone 6
potassium 5
glutamine 5
nicotinamide 5
DEAE 5
TCDD 5
GAP 5
ammonium 5
aldosterone 5
anthracene 5
NEU 5
SCC 5
cGMP 5
TCC 5
MIA 5
PEG 5
GM3 5
DBA 5
MBT 5
GSH 4
Thymidine 4
PGE2 4
Phorbol 4
ETA 4
CAT 4
CAT 4
noradrenaline 4
5-FU 4
TEM 4
Luminal 4
PAP 4
GSH 4
PAP 4
DMSO 4
4-chlorophenyl 4
butyric acid 4
Herbimycin 4
TSH 4
Curcumin 4
Tunicamycin 4
Emodin 4
CAT 4
PAP 4
PAS 4
Optimal 4
Paclitaxel 4
PAP 4
4-chlorophenyl 4
Cardiol 4
TRH 4
Androgen 4
HBr 4
uridine 4
boron 4
malonyl-CoA 4
glycerol 3
Collagen 3
MCA 3
more...