Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P04626 (
erbB-2
)
5,251
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Resveratrol and pterostilbene exhibit diverse biological activities.
MED28
, a subunit of the mammalian Mediator complex for transcription, was also identified as
magicin
, an actin cytoskeleton Grb2-associated protein, and as endothelial-derived gene (
EG-1
). Several tumors exhibit aberrant
MED28
expression, whereas the underlying mechanism is unclear. Triple-negative breast cancers, often expressing
epidermal growth factor (EGF) receptor
(EGFR), are associated with metastasis and poor survival. The objective of this study is to compare the effect of resveratrol and pterostilbene and to investigate the role of
MED28
in EGFR-overexpressing MDA-MB-231 breast cancer cells. Pretreatment of resveratrol, but not pterostlbene, suppressed EGF-mediated migration and expression of
MED28
and matrix metalloproteinase (MMP)-9 in MDA-MB-231 cells. Moreover, overexpression of
MED28
increased migration, and the addition of EGF further enhanced migration. Our data indicate that resveratrol modulates the effect of
MED28
on cellular migration, presumably through the EGFR/phosphatidylinositol 3-kinase (PI3K) signaling pathway, in breast cancer cells.
...
PMID:Resveratrol modulates MED28 (Magicin/EG-1) expression and inhibits epidermal growth factor (EGF)-induced migration in MDA-MB-231 human breast cancer cells. 2194 47
