Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P04626 (
erbB-2
)
5,251
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The expression of the
8-oxo-7,8-dihydrodeoxyguanosine triphosphatase
(
8-oxo-dGTPase
) gene in human breast tumors was evaluated at the level of the single cell to better understand how breast tumor cells regulate expression in response to oxidative stress. Compared to normal breast ductal cells, the level of
8-oxo-dGTPase
expression in the breast tumor cells increased from non-detectable levels in normal breast to expression in 30-85% of the tumor cells in individual tumors. There was no significant association between
8-oxo-dGTPase
expression and tumor grade and metastatic malignancy. The upregulation of
8-oxo-dGTPase
was not directly linked to the expression of cyclins D1 and D3, estrogen receptor, p53, Ki-67 and c-
erbB-2
, which are genes involved in cell cycle regulation and tumor growth. The elevated expression of
8-oxo-dGTPase
in human breast ductal carcinoma cells appears to be a general characteristic of breast tumors and may provide the tumor cell with a cellular defense mechanism to prevent the incorporation of 8-hydroxy-deoxyguanosine during DNA replication.
...
PMID:Enhanced expression of the 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase gene in human breast tumor cells. 956 6
