Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P04626 (
erbB-2
)
5,251
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Previously, we reported that
fetuin-A
is a major component of ovine foetal skin and significantly enhances 'wound closure' in primary keratinocyte cultures. In this study, we found that in human newborn foreskin, a high level of
fetuin-A
protein is detected throughout the dermis. However, in adult skin a low level of
fetuin-A
is observed throughout the epidermal and dermal layers, except at regions surrounding hair follicles and at the epidermal-dermal junction where the level of
fetuin-A
is relatively high.
Fetuin-A
significantly induces actin-rich protrusions in human primary keratinocytes. Interestingly, blockade of
epidermal growth factor (EGF) receptor
signalling has a limited effect on
fetuin-A
promoted 'wound closure' on primary human keratinocytes, but significantly inhibits
fetuin-A
's effect on HaCaT cells. These results indicate that high levels of
fetuin-A
may partially contribute to less scar formation in newborn foreskin and that the effect of
fetuin-A
on primary keratinocyte migration is independent of EGF receptor signalling.
...
PMID:Fetuin-A promotes primary keratinocyte migration: independent of epidermal growth factor receptor signalling. 1975 38
