Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P04626 (erbB-2)
 5,251 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The alterations of multiple genes and their carcinogenic mechanism in cervical carcinoma were studies by molecular hybridisation, PCR and PCR-ASO techniques. The G-T point mutation in the 12th coden of Ha-ras was detected in cervical carcinomas with mutation frequency of 18.2% (8/44), and the amplification rate of Ha-ras gene was 45% (9/20). The c-erb B2 was amplified 3-30 fold with an amplification rate of 73.3% (11/15) in cervical carcinomas and 5 cancerous samples showed gene rearrangement. The elevated copies of c-myc gene with amplification rate of 91.7% (11/12) were observed in cervical carcinomas. The study of HPV16 viral gene showed that the existence of HPV16 DNA sequence was positively associated with c-myc gene amplification in cervical cancerous samples. The p53 and Rb tumor suppressor genes absence of deletion were observed in the 12 specimens of cervical carcinoma investigated. As mentioned above, the study on alteration and carcinogenic mechanism of multiple genes indicated that 3 oncogenes and HPV16 viral gene were activated or integrated throygh different mechanisms and they played roles in co-carcinogenesis. The integration of HPV16 gene might promote the c-myc gene at the early stage in carcinogenesis of cervical carcinoma, while the alteration of Ha-ras and c-erb B2 gene might be middle-late event. As for the roles of the p53 and Rb tumor suppresor gene in cervical carcinogenesis need further researches.
Hua Xi Yi Ke Da Xue Xue Bao 1996 Mar
PMID:[Carcinogenic mechanisms of multiple genes in cervical carcinoma]. 920 11

In order to understand the relationship of C-erbB-2 oncogene overexpression to ER and PR in breast cancer and its prognostic significance, we examined overexpression of C-erbB-2 oncogene in 106 breast carcinomas by using immunohistochemical techniques (LSAB). The results showed that the positive rate of C-erbB-2 overexpression was 63.21% (67/106). The overexpression of C-erbB-2 oncogene related negatively with survival. 81.63% of the cases with overexpression of C-erbB-2 oncogene survived < or = 5 years and 34.29% survived > 10 years. There were significant associations of C-erbB-2 overexpression with advance clinical stage, high histological grade, and positive axillary node status in breast cancers. Negative relationship between hormone receptors and C-erbB-2 oncogene. All of these findings suggested that overexpression of C-erbB-2 oncogene might be an important prognostic factor and the detection of C-erbB-2 oncogene might be arranged as a regular pathological examination in the cases of breast cancer.
Hua Xi Yi Ke Da Xue Xue Bao 1997 Jun
PMID:[Relationship of C-erbB-2 oncogene overexpression to estrogen progesterone receptors in brease cancer and its prognostic significance]. 1068 38

pDOR-erbB-2 sense and antisense retroviral expression vectors were introduced into normal human diploid fibroblasts(2BS), respectively, to construct 2BS-A cells(transfected with antisense recombinant vector) and 2BS-S cells (transfected with sense recombinant vector). Southern blot analysis verified that the exgenous c-erbB-2 cDNA were integrated into genomic DNA. Compared with the cells transfected with pDOR-neo empty vector, 2BS-A cells exhibited decreased ability not only to repair DNA damage, but also to undergo apoptosis. This was consistent with our observations that senescent phenotype was earlier appeared in these cells.
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 2001
PMID:Antisense c-erbB-2 Decreases DNA Repair and Apoptosis Inducibility in Human Diploid Fibroblasts. 1204 Apr 17

In order to understand the expression of C-erbB-2 protein in breast cancer and its clinical significance, we examined the expression of C-erbB-2 protein in 106 breast carcinomas by using the immunohistochemical techniques LSAB. The results showed that the positive rate of C-erbB-2 expression was 63.21% (67/106). The overexpression of C-erbB-2 protein related negatively with survival. 81.63% of the cases with overexpression of C-erbB-2 protein survived < or = 5 years and 34.29% survived > 10 years. There were significant associations of C-erbB-2 overexpression with advanced clinical stage, high histological grade, and positive axillary node status in breast cancers. All of these findings suggested that overexpression of C-erbB-2 protein might be an important prognostic factor and the detection of C-erbB-2 protein might be arranged as a regular pathological examination in the cases of breast cancer.
Hua Xi Yi Ke Da Xue Xue Bao 1999 Mar
PMID:[Expression of C-erbB-2 protein in breast cancer and its clinical significance]. 1220 31