Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P04626 (erbB-2)
 5,251 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We studied the overexpression of c-erbB-2 and p21 oncoproteins in human radiation-induced skin ulcers using immunohistochemistry. We found that the positive rate of overexpression of c-erbB-2 and p21 oncoproteins was 92.0 and 92.9%, respectively. The overexpression of c-erbB-2 oncoprotein was observed mainly in the cell membrane of squamous epithelial cells and in the cytoplasm of fibroblasts, endothelial cells, leiomyocytes in the media, and in fibrocytes of the adventitia of mesenchymal arterioles. The location of the p21 oncoprotein overexpression was mostly similar to that of c-erbB-2 with stronger staining in the cytoplasm of squamous epithelial cells and weaker staining in mesenchymal arteriolar walls. The overexpression of c-erbB-2 and p21 oncoproteins may be corresponding to the cancer transformation and poor healing of radiation-induced skin ulcers.
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PMID:Overexpression of c-erbB-2 and p21 oncoproteins in human radiation-induced skin ulcers. 747 70

We established an animal model of radiation-induced skin ulcers in rats irradiated with 35-55Gy gamma-rays. The pathological changes were studied for 1 year. Immunohistochemical studies were performed on 72 radiation-induced skin ulcer specimens using c-erbB-2 and epidermal growth factor receptor (EGF-R) protein antibodies. We found that the overexpression rate of c-erbB2 oncoprotein was 59.7% and of EGF-R was 70.8%. The overexpression of c-erbB-2 was chiefly seen in the activated squamous epithelial cells and in the cytoplasm of fibroblasts, endothelial cells, and leiomyocytes of the arteriolar media in the deep part of the ulcers. The overexpression of EGF-R had the same localizations. It is suggested that the overexpression of c-erbB-2 and EGF-R proteins may be due to the poor healing of the radiation-induced skin ulcers.
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PMID:Overexpression of c-erbB-2 and EGF-R proteins in radiation-induced skin ulcers. 1528 Dec 43