Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P04626 (erbB-2)
 5,251 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Craniopharyngiomas (CP) were studied morphologically (52 cases), immunohistochemically (6 cases) and molecular-genetically (5 cases) in patients aged 18-65 years. Main causes of death early after surgery are disturbances in the hypothalamic region connected with surgical intervention. The highest lethality is observed after removal of extra-intraventricular neoplasms (44.4%). Lethality increases in patients with repeated surgery. Early postoperative lethality is much lower in the group of papillomatous CP. These tumors well expressed pancytokeratins, cytokeratin 14 and MUC-1, particularly in foci of pronounced keratinization. Oncoproteins c-kit and c-erbB-2 as well as estrogen and progesteron receptors were not observed. Proliferative activity (Ki-67) in CP is 11% in adamantinomatous CP and 2% in capillary CP and pronounced proliferation is observed around keratohyalin deposits. Accumulation of micromutations produced by the inactivation of genes "mismatch DNA reparation" is not typical for CP.
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PMID:[Craniopharyngiomas in the adults]. 1620 98