Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P04179 (MnSOD)
 2,777 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study aims to use manganese-enhanced MRI (MEMRI) to investigate the progression and permanence of the gray matter injuries in a neonatal rat model by mild hypoxic-ischemia (H-I) insult. Histological analyses were performed using staining for Mn superoxide dismutase (Mn-SOD) and glutamine synthetase (GS), which are Mn-binding enzymes against oxidative stress and glutamate excitotoxicity in neurodegeneration, and the standard hematoxylin and eosin (H&E). The transient changes associated with gray matter injuries in T(2)-weighted image (T2WI) and diffusion weighted image (DWI) in acute phase were shown to be detectable using MEMRI in late phase by systemic Mn(2+) administration, correlating with the local cell death, GS and Mn-SOD increase. Therefore, MEMRI may be a potentially useful diagnostic paradigm for detecting the gray matter injuries that are otherwise undetectable using the current MRI techniques in late phase of mild H-I injury.
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PMID:Manganese-enhanced MRI detected the gray matter lesions in the late phase of mild hypoxic-ischemic injury in neonatal rat. 1800 86

This study aims to employ in vivo manganese-enhanced MRI (MEMRI) to detect neurodegenerative changes in two models of brain ischemia, photothrombotic cortical injury (PCI) and transient middle cerebral artery occlusion (MCAO) in rodents. After systemic Mn(2+) injection to both ischemic models, a close pattern of T1-weighted hyperintensity was observed throughout different brain regions in comparison to the distribution of GFAP, MnSOD and GS immunoreactivities, whereby conventional MRI could hardly detect such. In addition, the infarct volumes in the posterior parts of the brain had significantly reduced after Mn(2+) injection to the MCAO model. It is suggested that exogenous Mn(2+) injection may provide enhanced MEMRI detection of oxidative stress and gliosis early after brain ischemia. Manganese may also mediate infarctions at remote brain regions in transient focal cerebral ischemia before delayed secondary damage takes place.
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PMID:Early detection of neurodegeneration in brain ischemia by manganese-enhanced MRI. 1916 61