Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P04179 (
MnSOD
)
2,777
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The
LEC
rat is a mutant strain displaying hereditary hepatitis and hepatoma. We established enzyme-linked immunosorbent assays of Cu,Zn- and Mn-superoxide dismutase (Cu,Zn- and
Mn-SOD
) and measured the levels of both SODs in various organs of
LEC
and Wistar rats.
Mn-SOD
concentrations were higher in
LEC
rats than in Wistar rats in most tissues. Cu,Zn-SOD levels of liver, kidney and intestine were lower in
LEC
rats than in Wistar rats. Atomic absorbtion techniques indicated that in addition to high Cu concentrations as previously reported,
LEC
rat livers contained high Fe concentrations relative to those in Wistar rat livers. These data suggest that increased concentrations of Fe and Cu and decreased levels of Cu,Zn-SOD may facilitate the Fenton reaction to produce hydroxyl radicals in the tissues of the
LEC
rat. To compensate for the decreased scavenging effects due to low levels of Cu,Zn-SOD, an adaptive increase of
Mn-SOD
may occur in the process of hepatitis and hepatocarcinogenesis in
LEC
rats.
...
PMID:High copper and iron levels and expression of Mn-superoxide dismutase in mutant rats displaying hereditary hepatitis and hepatoma (LEC rats). 840 14
