Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P04179 (
MnSOD
)
2,777
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Studies have been conducted to examine the implications of photochemical generation of O2- and its derivatization to H2O2 and OH . in the physiology of the lens in vitro. Physiological status was determined by measuring the uptake of
rubidium
by the intact tissue when cultured in riboflavin-containing medium, in dark and light, and in the presence and absence of various scavengers. In the presence of light, the uptake of
rubidium
in the lens was greatly diminished; this suggests photodamage to the tissue.
MnSOD
and ferricyanide protected against this photochemical damage. The damaging process was thus initiated by the generation of O2-. The tissue damage was also attenuated by catalase, ferrocyanide, and mannitol. These results, therefore, suggest the participation of hydrogen peroxide and the subsequent Haber-Weiss reaction in the photodamaging process.
...
PMID:Photodamage to the lens in vitro: implications of the Haber-Weiss reaction. 243 8
