Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P04179 (MnSOD)
 2,777 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Root resorbing of deciduous teeth is a general phenomenon during eruption of the permanent teeth. In the present study, we tried to clarify the active-oxygen metabolism of root resorped granulated tissues. Granulated tissues were obtained from two fresh mandibles of young bovine about 1 year old undergoing root resorption. Cu-Zn-Superoxide dismutase (SOD), Mn-SOD, Lactate dehydrogenase (LDH), and concentration of lipid-peroxidated products were determined on the supernatants from homogenized tissues. We obtained the following results. 1) Cytosolic Cu-Zn-SOD activity did not elevate as compared to control tissues. 2) Elevation of mitochondrial Mn-SOD activity was observed in granulated tissues. 3) LDH activity did not elevate as compared to control tissues. 4) Lipid-peroxidated products in granulated tissues showed high concentration as compared to control tissues. Based on the above, we specurated that the active-oxygen metabolism in the root resorped granulated tissues, at least in mitochondria, was elevated.
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PMID:[Oxygen metabolism in roots resorbing granulated tissue from bovine deciduous teeth, from the aspects of superoxide dismutase, lactate dehydrogenase, and lipid peroxidation]. 248 84