Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P04179 (MnSOD)
 2,777 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It is reviewed the achievements in the field of radiation-genetics investigations of low doze radiation influence on life span. It is suggested that life span decreasing after irradiation is due to stress-induced premature cell senescence. Life span increasing after irradiation, possibly, is connected with stress-induced activation of FOXO transcription factors, which induce on the basis of stress depth: 1) genes of stress tolerance (MnSOD, catalase, GADD45, p27), 2) apoptosis genes (Bim, FasL). Stress-resistance as well as apoptosis of damaged cells can attenuate aging. In generations of chronic irradiation life span increasing may be due to inbreeding depression removal in populations of laboratory animals.
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PMID:[Genetic investigations of low doze irradiation influence on life span]. 1866 44