Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P04179 (
MnSOD
)
2,777
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Competitive glutamate receptor antagonists APV and
CNQX
were injected with kainate unilaterally into CA3 region of the rat hippocampus. They both expressed sufficient neuroprotection in the sense of decreasing superoxide production and increasing
MnSOD
levels, but with differential effect in mechanisms and time dynamics. Our findings suggest that NMDA and AMPA/kainate receptors are differentially involved in superoxide production, and they also impose different neuroprotective effects on the induction of
MnSOD
activity in hippocampus.
...
PMID:Mitochondrial superoxide production and MnSOD activity after exposure to agonist and antagonists of ionotropic glutamate receptors in hippocampus. 2601 48
