Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P04179 (MnSOD)
 2,777 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Clinical and biological features indicate that a dysregulation of microbicidal activity occurs in the cells of mononuclear phagocytic lineage of HIV-1-infected patients. Thus, the regulation of MnSOD gene expression has been investigated during the 10 h following in vitro HIV macrophage infection. As previously reported, in HIV-1 LAI-infected macrophages a high expression of the MnSOD gene is observed 2 and 4 h after infection. These results are confirmed when cells are infected with three macrophage-tropic strains HIV-1, DAS, PAR and Bal. Moreover, the detection of the MnSOD gene expression in the macrophage cultures is associated with the cellular tropism of the viral strains used. The binding of recombinant GP160 by itself is not sufficient to induce MnSOD expression. In fact, the same MnSOD gene induction was obtained with the heat inactivated viral isolates, indicating that these phenomena are due to the viral entry. On the other hand, phagocytosis of latex beads triggers a high expression of the MnSOD gene in macrophages, showing that phagocytosis of HIV may be sufficient to induce the expression of that gene. Taken together, these results indicate that the MnSOD gene expression observed within 10 h following infection of macrophages is mainly related to membrane biophysical unspecific modifications.
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PMID:Effect of human immunodeficiency virus type 1 (HIV-1) monocyte-derived macrophages infection on the manganous superoxide dismutase gene expression. 819 28

Ischemia/reperfusion (I/R) injury-induced oxidative stress plays an important role in the functional impairment of the bladder following acute bladder outlet obstruction (BOO) via induction of apoptosis. The purpose of this study was to investigate the time course of the bladder apoptosis, and apoptosis related molecular changes in the early stage of acute BOO. Twelve-week-old male Sprague Dawley rats were divided into control, acute BOO only (I), and acute BOO plus subsequent emptying (I/R) for 30, 60, 120 min, 3 days and 2 weeks. We examined the extent of bladder apoptosis, expression of Mn-superoxide dismutase (Mn-SOD), Bcl-2, Bax, caspase 3 and poly (ADP-ribose) (PAR) in the bladder. Bladder apoptosis was significantly increased in the I/R group at 30, 60, and 120 min following bladder emptying. BOO plus subsequent emptying for 30, 60, 120 min showed significant decrease in MnSOD and Bcl-2 expression, and significant increase in caspase 3, Bax expression, and amounts of PAR. These results indicate that bladder apoptosis, induced by acute BOO and subsequent emptying, is associated with decreased MnSOD expression, increased PARP activity and imbalance in apoptosis pathways.
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PMID:Time dependent bladder apoptosis induced by acute bladder outlet obstruction and subsequent emptying is associated with decreased MnSOD expression and Bcl-2/Bax ratio. 2106 Jul 56