Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P04179 (
MnSOD
)
2,777
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The abundance of cellular superoxide dismutase (
Mn-SOD
) was examined immunocytochemically in different regions of the brain of Long-Evans Cinnamon (LEC) rats at 4 and 50 weeks of age. When all animals develop chronic hepatitis, the substantia nigra and striatum showed a marked increase in
Mn-SOD
immunoreactivity versus Long-Evans agouti (LEA) rats of the same age.
Mn-SOD
was localized predominantly in dopaminergic neurons. The elevation of
Mn-SOD
level in the dopaminergic neurons of LEC rats may reflect the oxidative stress caused by copper accumulation in this brain area. Our data suggest that LEC rats may contribute to the mechanistic study of neurological manifestations in nigro-striatal dopaminergic system of
Wilson's disease
.
...
PMID:Enhanced Mn-SOD immunoreactivity in the dopaminergic neurons of long-evans cinnamon rats. 1607 18
