Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P04179 (MnSOD)
 2,777 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. The activity of manganese-superoxide dismutase (EC 1.15.1.1; SOD) was increased in the livers and kidneys of adult rats after exposure to aqueous ethanol (200 ml/1) for 32 weeks. 2. The concentration of Mn in the livers and kidneys was significantly higher after 24 weeks, and by 32 weeks liver copper and zinc levels were lower. 3. The activity of foetal (day 19) liver superoxide dismutase was appreciably higher in offspring from dams receiving ethanol during pregnancy. Quantitatively the response appeared to be almost entirely due to the Mn-SOD form of the enzyme. 4. Maternal alcoholism during pregnancy had no effect on the levels of Cu, Mn or Zn in foetal (day 19) livers.
 ...
PMID:Superoxide dismutase (EC 1.15.1.1), manganese and the effect of ethanol in adult and foetal rats. 688 37

Oxidative stress-associated parameters [concentrations of lactoferrin, Cu,Zn-superoxide dismutase (SOD) and Mn-SOD] were determined in sera of 20 patients suffering from alcohol dependence immediately after detoxification and in 15 non-dependent healthy subjects as controls. In the patient group, the mean Mn-SOD concentration reached almost double the values of those from the control group (142.9 vs 76.0 ng/ml, P < 0.01). The other parameters tended to be increased in patients, but did not differ significantly between index and control groups. The findings are consistent with increased oxidative stress due to chronic alcohol intake, which might be responsible for secondary diseases such as brain atrophy, peripheral polyneuropathy and liver fibrinogenesis.
 ...
PMID:Increased concentrations of manganese superoxide dismutase in serum of alcohol-dependent patients. 913 93