Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P04155 (
pS2
)
1,234
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Immunophenotypes of mammary (
MPD
) and extramammary Paget's disease (EPD) are still not well understood. Thirty-four formalin-fixed paraffin-embedded tissue sections from 33 patients with 6
MPD
and 28 EPD were studied immunohistochemically with the use of polyclonal c-erbB-2 and
pS2
antisera, and monoclonal nm23, B6.2, GCDFP-15, and p53 antibodies. Cases of
MPD
expressed a high incidence of c-erbB-2 and nm23 compared with those of EPD (100% vs. 29%; p < 0.01, and 83% vs. 29%; p < 0.05, respectively). Although high expression of B6.2 (> 83%) and moderate expression of GCDFP-15 (33-39%),
pS2
(33-46%) and p53 (39-50%) were seen, the positivity was not significantly different between
MPD
and EPD. These findings indicate that
MPD
and EPD share immunohistochemical features but partially differ in their patterns of antigen expression.
...
PMID:Immunohistochemical study of mammary and extramammary Paget's disease. 776 23
