Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P04155 (
pS2
)
1,234
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Trefoil family factor (TFF) proteins contribute to antimicrobial defense and the maintenance of sinonasal epithelial barrier integrity. Dysregulation of TFF expression may be involved in the development of chronic inflammation and tissue remodeling characteristically found in chronic rhinosinusitis with nasal polyposis (CRSwNP). Expressions of
TFF1
and
TFF3
were determined in specimens of middle nasal turbinate (
MNT
-0), bulla ethmoidalis (BE), and nasal polyps (NP) from CRSwNP patients (
n
= 29) and inferior nasal turbinate from a group of control patients (underwent nasal septoplasty,
n
= 25). An additional
MNT
sample was collected 6 months after functional endoscopic sinus surgery (FESS,
MNT
-6).
TFF1
mRNA levels were significantly reduced in all specimens by approximately three- to five-fold, while
TFF3
was increased in
MNT
-0, as compared with controls. Six months after surgery their levels were reversed to control values. CRSwNP patients with
S. epidermidis
isolated from sinus swabs showed upregulation of
TFF3
in
MNT
and NP as compared with patients with sterile swabs. Target gene regulation was not affected by the presence of type 2 inflammation in patients with confirmed allergy. Results of this study imply participation of
TFFs
genes in the development of CRSwNP.
...
PMID:Differential Expression of
TFF1
and
TFF3
in Patients Suffering from Chronic Rhinosinusitis with Nasal Polyposis. 3168 88
