Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P04155 (
pS2
)
1,234
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
TFF1
is a protective peptide of the Trefoil Factor Family (TFF), which is co-secreted with the mucin MUC5AC, gastrokine 2 (GKN2), and IgG Fc binding protein (FCGBP) from gastric surface mucous cells.
Tff1
-deficient mice obligatorily develop antropyloric adenoma and about 30% progress to carcinomas, indicating that Tff1 is a tumor suppressor. As a hallmark,
TFF1
contains seven cysteine residues with three disulfide bonds stabilizing the conserved TFF domain. Here, we systematically investigated the molecular forms of
TFF1
in the human gastric mucosa.
TFF1
mainly occurs in an unusual monomeric form, but also as a homodimer. Furthermore, minor amounts of
TFF1
form heterodimers with GKN2, FCGBP, and an unknown partner protein, respectively.
TFF1
also binds to the mucin MUC6 in vitro, as shown by overlay assays with synthetic
125
I-labeled
TFF1
homodimer. The dominant presence of a monomeric form with a free thiol group at Cys-58 is in agreement with previous studies in
Xenopus laevis
and mouse. Cys-58 is likely highly reactive due to flanking acid residues (PPEEEC
58
EF) and might act as a scavenger for extracellular reactive oxygen/nitrogen species protecting the gastric mucosa from damage by oxidative stress, e.g., H
2
O
2
generated by
dual oxidase
(
DUOX
).
...
PMID:The Tumor Suppressor TFF1 Occurs in Different Forms and Interacts with Multiple Partners in the Human Gastric Mucus Barrier: Indications for Diverse Protective Functions. 3226 Mar 57
