Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P04141 (granulocyte-macrophage colony-stimulating factor)
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Human Gene/Protein
phospholipase C, beta 2 12.2
granulocyte-macrophage colony-stimulating factor 12.2
Mast cell growth factor 11.2
transforming growth factor, beta 2 11.2
hematopoietin-1 11.2
interleukin 3 receptor alpha subunit 11.2
TJAP1 11.2
metastatic lymph node 51 11.0
HOX B6 10.6
Chemokine (C-C motif) ligand 17 10.6
CMG1 10.6
GM-CSF receptor 10.3
betac 10.2
VL4 10.2
CSF2RA 10.2
Radioprotective 105 kDa protein 10.2
colony stimulating factor 3 9.9
cytokine inducible SH2-containing protein 9.9
CSF2RB 9.7
GRF55 9.6
FARSB 9.6
CDw131 9.6
complement component 4A 9.6
Interleukin-3 9.6
ADP-ribosyltransferase 3 9.4
SPOCK3 9.4
stem cell factor, SCF 9.4
Magmas 9.3
TREML4 9.2
hematopoietic progenitor cell antigen CD34 9.2
GMFB 9.2
PDE1B1 9.2
CCC6 9.2
CSF2 9.2
Tissue-specific extinguisher 1 9.0
IL-3 9.0
zinc finger protein 36 8.9
ABLIM 8.9
FLT3L 8.9
CSF1R protein 8.9
granulocyte colony-stimulating factor 8.8
HLA-DRB3*01 8.7
BAZF 8.7
RNA-binding motif protein 15 8.7
Mucin 4 8.7
aldesleukin 8.7
20-alpha-hydroxysteroid dehydrogenase 8.6
ocrl1 8.6
pim-1 protein 8.6
MT-IF 8.6
phenylalanine-tRNA synthetase 8.6
KRT23 8.6
STAM1 8.6
PDE1B 8.5
stem cell factor 8.5
G protein-coupled receptor 84 8.5
DNAJC15 8.5
CCR11 8.5
mast cell growth factor 8.5
granulocyte-macrophage 8.4
hSBP 8.3
Stat5A 8.3
monocyte chemotactic protein-3 8.3
Flt3 ligand 8.2
BAC1 8.2
FDC 8.1
integrin beta-3 8.1
Leukotactin-1 8.1
ASD2 8.1
macrophage colony-stimulating factor 8.1
JEM-1 8.0
MUC3A 8.0
HOXB2 8.0
NDUFA10 8.0
megakaryocyte growth and development factor 8.0
Tim14 7.9
TLS-ERG 7.9
Mgn 7.9
ETV7 7.9
IRG2 7.9
more...
Disease
untreated adult AML 9.6
CNS candidiasis 9.6
Episodic angioedema with eosinophilia 9.6
C cell tumor 9.4
Amegakaryocytic thrombocytopenia 9.2
pulmonary alveolar proteinosis 9.1
ASD2 9.0
Chronic neutropenia 8.7
FAB M4Eo 8.7
Candida tropicalis infection 8.6
Paragonimus westermani infection 8.6
juvenile myelomonocytic leukemia 8.5
Granulocytosis 8.4
Acute mucositis 8.3
Post-weaning multisystemic wasting syndrome 8.2
FDC 8.1
histiocytic leukemia 8.0
Myelokathexis 7.9
Hypersensitivity syndrome 7.8
stage IV renal cell carcinoma 7.7
WT3 7.6
relapsed CML 7.3
KHM 7.2
HPP 6.9
FAB M2 6.8
HPP 6.8
MAC bacteremia 6.8
Ureaplasma infection 6.7
Cyclic neutropenia 6.6
severe congenital neutropenia 6.6
FHL3 6.4
ovarian mucinous cystadenocarcinoma 6.4
stage II melanoma 6.4
Testicular Cancer 6.3
androgen independent prostate cancer 6.3
myeloid leukemia 6.3
uterine neoplasm 6.3
recurrent thyroid cancer 6.3
ACTH-secreting pituitary adenoma 6.3
Legionella pneumophila pneumonia 6.2
RAEB-T 6.2
Neutropenic enterocolitis 6.2
Felty's syndrome 6.2
Neovascular age-related macular degeneration 6.2
neutropenia 6.1
ovarian cancer stage 6.1
Bone marrow depression 6.1
Gram-positive bacteremia 6.1
pseudocowpox 6.1
Johanson-Blizzard syndrome 6.1
megakaryocytic leukemia 6.1
Bacterial sepsis 6.0
metastatic Ewing's sarcoma 6.0
bone marrow disorder 6.0
Influenza A virus infection 6.0
Idiopathic pulmonary arterial hypertension 6.0
Apical periodontitis 5.9
IgG myeloma 5.9
myelosuppression 5.9
polyarticular arthritis 5.8
mast cell leukemia 5.8
chronic neutrophilic leukemia 5.7
high-risk cancer 5.7
leukemoid reaction 5.7
refractory anemia 5.7
LAD2 5.7
Opioid use disorder 5.6
stage IV melanoma 5.6
aplastic anemia 5.6
Prostate tumor 5.6
RARS 5.6
Eosinophilia 5.6
Schistosoma haematobium infection 5.5
acute undifferentiated leukemia 5.5
ADCC 5.5
MIP 5.4
monocytic leukemia 5.4
Yersinia enterocolitica infection 5.4
Febrile neutropenia 5.4
agranulocytosis 5.4
more...
Symptom
epigastric distress 6.6
generalized abdominal pain 5.6
bone pain 5.3
generalized rash 5.0
rigors 4.1
belching 3.5
hepatosplenomegaly 3.1
myalgia 3.0
persistent cough 2.9
chills 2.7
splenomegaly 2.6
chest tightness 2.6
exertional dyspnea 2.5
clubbing 2.4
oliguria 2.3
cachexia 2.3
HSA 2.2
nasal congestion 2.0
hyperoxia 1.8
erythema 1.8
dyspnea 1.8
lethargy 1.7
arthralgia 1.7
skin damage 1.6
exhaustion 1.6
flushing 1.6
wheezing 1.6
bloating 1.5
respiratory distress 1.4
nausea 1.3
skin irritation 1.1
cough 1.1
Ill 1.1
pallor 0.9
Wind 0.8
diarrhea 0.6
acute abdomen 0.6
discomfort 0.6
nausea and vomiting 0.6
discomfort 0.4
cyanosis 0.3
vomiting 0.2
hemiplegia 0.2
pelvic pain 0.2
functional recovery 0.1
syncope 0.0
headache -0.1
fatigue -0.1
agitation -0.4
starvation -0.4
anorexia -0.6
ataxia -0.8
hypothermia -0.9
pain -0.9
dizziness -1.0
abdominal pain -1.1
anesthesia -1.2
weakness -1.4
Welt -1.8
chest pain -1.9
tremor -2.0
seizures -2.5
analgesia -2.6
Drug
Leukine 11.6
Fusidic Acid 11.2
Belagenpumatucel-L 9.9
Provenge 8.0
Purvalanol 7.7
CSF 7.6
Filgrastim 7.5
Filgrastim 7.4
G-CSF 7.3
IL-11 7.2
Novantrone 7.1
Proleukin 7.1
Olopatadine hydrochloride 7.1
LCM 6.9
LCM 6.9
Anagrelide 6.7
Crotonaldehyde 6.5
Synercid 6.3
Ebastine 6.2
anti-CD33 6.1
Vesnarinone 5.9
Ciglitazone 5.9
IL-1ra 5.8
EML 5.8
IL-2 5.8
Fragmin 5.6
Engerix-B 5.5
Ethyol 5.4
Intron A 5.4
Red ginseng 5.3
Methylcellulose 5.3
Zevalin 5.2
IFN-gamma 5.2
Intron A 5.2
Intron A 5.1
Ipilimumab 5.1
IFN-beta 5.0
Dithranol 4.9
Zileuton 4.9
NLF 4.9
Bromelain 4.8
Imiquimod 4.7
p75 4.7
Navelbine 4.7
Amifostine 4.7
Hypaque 4.7
CCL 4.7
Daclizumab 4.7
Nedocromil sodium 4.6
Micafungin 4.5
Hypaque 4.5
Budesonide 4.5
PE2 4.4
FCV 4.3
Amrinone 4.3
Ammonium chloride 4.3
Pirfenidone 4.3
G418 4.2
Anakinra 4.2
TEL 4.2
Epoetin 4.1
KCL 4.1
Dasatinib 4.0
Myricetin 3.9
Taxotere 3.9
VCR 3.9
K-252a 3.8
AraC 3.7
Gleevec 3.7
Dalteparin 3.7
Prednisolone 3.7
Ganciclovir 3.6
AZT 3.6
VCR 3.6
MDM 3.5
Aminoguanidine 3.5
Vinorelbine 3.5
AZT 3.4
beta-Galactosidase 3.4
ddI 3.4
more...
Enzyme
phosphoglucokinase 9.9
protein O-D-mannosyltransferase 9.6
retinal dehydrogenase 7.1
deoxycytidine deaminase 5.8
p80 5.7
polypeptide N-acetylgalactosaminyltransferase 5.7
MIP 5.5
CD13 5.3
LTC4 synthase 5.3
macrophage elastase 5.0
prostasin 5.0
arachidonate 5-lipoxygenase 5.0
inosine triphosphatase 4.9
3'-phosphatase 4.8
deoxycytidine kinase 4.7
Thy1 4.5
PTPase 4.5
cruzipain 4.5
alpha-sarcin 4.4
inositol 3-kinase 4.3
peptide deformylase 4.3
BAL 4.2
cytosine deaminase 4.2
arginase 4.1
IgA1 protease 4.1
SpeB 4.1
phosphatidylinositol 3-kinase 4.0
p100 4.0
MTD 4.0
tryptase 3.9
factor C 3.9
ceramidase 3.8
thyroid peroxidase 3.8
farnesyltransferase 3.8
FPS 3.8
caspase-11 3.8
caspase-11 3.7
indoleamine 2,3-dioxygenase 3.7
phenylalanyl-tRNA synthetase 3.7
thymidine kinase 3.7
cathepsin H 3.7
granzyme B 3.7
matriptase 3.6
prostacyclin synthase 3.6
PNGase F 3.6
15-lipoxygenase 3.6
legumain 3.6
dextranase 3.6
TACE 3.6
chymopapain 3.5
HCS 3.5
caspase-4 3.5
TSP-1 3.5
chymopapain 3.4
choline kinase 3.4
chymase 3.4
tyrosinase 3.4
reverse transcriptase 3.4
MEK 3.4
lipoxygenase 3.4
PAM 3.3
phospholipase D 3.3
histone demethylase 3.3
caspase-6 3.3
glucosylceramide synthase 3.3
lysostaphin 3.3
DCF 3.3
diacylglycerol kinase 3.2
caspase-6 3.2
farnesyltransferase 3.2
matriptase 3.2
neutrophil elastase 3.2
chloramphenicol acetyltransferase 3.2
bromelain 3.2
S1 nuclease 3.2
BMT 3.1
HtrA 3.1
mitogen-activated protein kinase 3.1
IKK 3.1
focal adhesion kinase 3.1
more...
Compound
11H-indeno[1,2-b]quinoxalin-11-one 9.4
1-pyrrolidinecarbodithioic acid 9.2
Cortivazol 9.0
Mafosfamide 8.4
Ammonium pyrrolidine dithiocarbamate 8.2
Mometasone 8.2
Biebrich scarlet 8.1
2-naphthalenesulfonamide 7.7
LXB4 7.6
Myristicin 7.6
Actinonin 7.4
Beclomethasone 7.4
EPA ethyl ester 6.8
Perfluorodecalin 6.6
fMet 6.5
Fluocinolone acetonide 6.4
Coumermycin 6.4
DT3 6.3
Cortisone acetate 6.3
Roxithromycin 6.2
Ara-C 6.1
WY-14,643 6.1
FMLP 6.0
Hygromycin B 6.0
NFS 6.0
F23 6.0
TFF 6.0
Escin 5.9
Escin 5.9
IAA-94 5.9
Ingenol 5.9
CMK 5.8
Ara-C 5.8
ABT-773 5.8
20-COOH-LTB4 5.7
FOA 5.6
GDP-L-fucose 5.6
Interleukin-2 5.6
Diallyl disulfide 5.5
Diallyl disulfide 5.5
HPP 5.5
Herbimycin 5.4
2-butenal 5.4
Lipoxin A4 5.3
Guanabenz 5.3
dolichyl-phosphate 5.2
LTC4 5.2
15(S)-HETE 5.2
Lithocholic acid 5.1
8-iso-PGF2alpha 5.1
BAF 5.0
DDM 5.0
1,2,4-benzenetriol 5.0
Benzidine 5.0
Trovafloxacin 4.9
IDC 4.9
Dithranol 4.9
TTNPB 4.9
2-methylpiperazine 4.9
Phorbol 12-myristate 13-acetate 4.8
1,3-butanediol 4.8
AA861 4.7
Actinomycin D 4.7
1,3-butanediol 4.7
NMA 4.6
Sudan IV 4.6
WR-1065 4.6
Cbl 4.6
thioglycollate 4.5
Lentinan 4.5
neopterin 4.5
VLA 4.5
Hypaque 4.4
prostaglandin J2 4.4
Tumor Necrosis Factor 4.4
Cetirizine 4.4
Dexamethasone 4.4
Deoxycoformycin 4.4
Polybrene 4.4
Formoterol 4.3
more...