Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P04141 (granulocyte-macrophage colony-stimulating factor)
 6,790 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
granulocyte-macrophage colony-stimulating factor 6790
cytokine 1701
CSF 831
granulocyte colony-stimulating factor 707
tumor necrosis factor 697
IL-3 656
IL-6 651
IL-4 525
Sep 478
IL-5 476
granulocyte 458
interferon 451
macrophage colony-stimulating factor 437
GM-CSF 418
interferon-gamma 387
lipopolysaccharide 382
IL-10 368
erythropoietin 349
IL-2 337
IL-8 336
Mol 325
stem cell factor 321
erythroid 302
tumor necrosis factor alpha 301
interleukin-4 297
CD4 276
granulocyte-macrophage 262
interleukin-6 256
interleukin-2 250
Cytokine 237
GM-CSF receptor 234
IFN-gamma 232
IL-1 228
IL-1 beta 217
IFN 215
TNF 205
CD34 184
CD8 179
lymphoid 175
Interleukin-3 170
G-CSF 168
TNF-alpha 164
CD14 151
CD86 150
IL-1 alpha 137
chemokine 136
CD11b 134
HLA-DR 129
CD80 122
c-kit 114
c-fms 114
tyrosine kinase 113
IL-13 113
interferon gamma 111
CD40 107
megakaryocyte 106
lymphokine 101
major histocompatibility complex 100
interleukin 6 92
CD11c 91
IL-17 91
HLA 89
thrombopoietin 88
CD1a 82
glycoprotein 80
IL-7 78
CD83 77
MHC class II 75
transforming growth factor-beta 75
RANTES 72
ICAM-1 68
collagen 62
vascular endothelial growth factor 62
p38 62
interleukin-10 61
MHC 61
STAT5 61
IgE 61
mast cell growth factor 59
CD16 58
interleukin 2 58
LPS 56
fused 56
cytokine receptor 56
interferon-alpha 56
lymphotoxin 55
c-fos 50
Tumor necrosis factor 50
mast cell 50
IL-15 49
MAPK 48
TGF-beta 48
polypeptide 48
CFC 47
MIP 47
proto-oncogene 46
thymus 45
c-myc 45
platelet-derived growth factor 44
intercellular adhesion molecule-1 44
Fas 44
STAT 44
eotaxin 43
IL-2 receptor 43
MIP-1alpha 43
monocyte chemoattractant protein 43
monocyte chemoattractant protein-1 42
non-Hodgkin's lymphoma 42
mitogen-activated protein 42
AP-1 42
extracellular signal-regulated kinase 42
CD38 41
fibronectin 41
CD28 41
Flt3 ligand 40
FDC 40
CD25 39
leukemia inhibitory factor 38
myeloperoxidase 38
adhesion molecule 38
phosphatidylinositol 3-kinase 38
alpha-chain 38
CD45 38
CD18 38
MHC class I 38
THP 38
CD33 37
IL-11 37
MCP-1 36
epidermal growth factor 36
esterase 36
CCL2 35
ERK 34
ERK1 34
IL-18 34
Bcl-2 34
JAK2 33
lectin 33
p53 33
insulin 33
gut 33
Leukemia inhibitory factor 32
TLR4 32
MAP kinase 32
Fc gamma 32
IL-9 31
NOD 31
hemoglobin 31
SCF 31
AML 31
p70 31
CD13 30
p65 29
major histocompatibility complex class II 28
MEK 28
Erythropoietin 28
CXCL10 28
serum albumin 27
caspase-3 27
monocyte chemotactic protein 27
more...
Disease
cancer 816
tumor 729
leukemia 427
acute myeloid leukemia 306
neutropenia 263
melanoma 175
HIV 146
asthma 141
immunodeficiency 137
myelodysplastic syndrome 128
Leukemia 124
lymphoma 118
carcinoma 98
eosinophilia 97
pulmonary alveolar proteinosis 97
AIDS 94
tumor growth 91
chronic myeloid leukemia 89
breast cancer 84
rheumatoid arthritis 84
thrombocytopenia 83
myelosuppression 75
sepsis 75
infectious diseases 74
Mycobacterium 71
sepsis 71
metastases 70
myeloid leukemia 67
aplastic anemia 61
multiple myeloma 61
pneumonia 59
anemia 57
herpes simplex 52
influenza 50
multiple sclerosis 50
Hodgkin's disease 50
MIP 47
tuberculosis 47
graft-versus-host disease 44
prostate cancer 44
virus infection 44
lung cancer 44
juvenile myelomonocytic leukemia 42
SCID 42
adenocarcinoma 42
non-Hodgkin's lymphoma 40
FDC 40
vaccinia 39
acute lymphoblastic leukemia 39
leukopenia 38
arthritis 38
Infection 38
agranulocytosis 36
encephalomyelitis 34
lung disease 33
sarcoma 32
NOD 31
tumor progression 31
autoimmune disease 31
suicide 31
acute leukemia 31
cytomegalovirus 30
diphtheria 29
metastatic melanoma 29
allergic rhinitis 28
pertussis 27
tetanus 27
lung carcinoma 27
erythroleukemia 26
plaque 26
Crohn's disease 26
renal cell carcinoma 25
hepatocellular carcinoma 25
myeloproliferative disorders 25
atherosclerosis 25
chronic obstructive pulmonary disease 25
glioma 24
neuroblastoma 24
colorectal cancer 24
atopic dermatitis 24
bacterial infection 23
uterus 23
DBA 23
squamous cell carcinoma 22
leukemogenesis 22
systemic lupus erythematosus 22
SEM 22
inflammatory bowel disease 22
ovarian cancer 22
Melanoma 21
pancytopenia 20
chronic lymphocytic leukemia 20
fungal infection 20
diabetes 20
SDS 20
non-small cell lung cancer 19
psoriasis 19
tumorigenesis 19
Epstein 19
acute promyelocytic leukemia 18
MAC 18
minimal residual disease 18
Blocking 18
hematologic malignancies 18
pulmonary fibrosis 18
hepatitis B 17
malaria 17
stroke 17
solid tumor 17
rash 16
primary tumor 16
depression 16
aspergillosis 16
sarcoidosis 15
carcinogenesis 15
HPP 14
respiratory failure 14
PHA 14
metastatic renal cell carcinoma 14
HPP 14
lymphocytic choriomeningitis 13
dengue 13
glioblastoma 13
candidiasis 13
B-cell lymphoma 13
metastatic breast cancer 13
obesity 13
ischemia 13
leishmaniasis 13
refractory anemia 13
residual disease 12
Tumour necrosis 12
cold 12
lymphoblastic leukemia 12
Cryptococcus neoformans 12
chronic granulomatous disease 12
periodontitis 12
vasculitis 11
hypertension 11
osteoarthritis 11
Alzheimer's disease 11
colon cancer 11
ABL 11
Kaposi's sarcoma 11
bacteremia 11
chronic hepatitis 11
Mycoplasma 11
sickle cell disease 11
osteosarcoma 11
dermatitis 11
rare disease 11
small cell lung cancer 10
choriocarcinoma 10
cholera 10
skin disease 10
bladder cancer 10
PAF 10
epithelial ovarian cancer 10
hepatitis C 10
chronic lymphocytic leukemia 10
more...
Symptom
pain 30
bone pain 26
dyspnea 21
diarrhea 19
splenomegaly 13
nausea 12
myalgia 11
cough 11
headache 11
respiratory distress 11
fatigue 10
anesthesia 10
erythema 10
exhaustion 9
vomiting 8
hepatosplenomegaly 8
discomfort 7
discomfort 7
cachexia 6
chills 6
arthralgia 5
Ill 5
starvation 4
exertional dyspnea 4
hyperoxia 4
lethargy 4
flushing 4
weakness 3
nausea and vomiting 3
HSA 3
rigors 3
abdominal pain 3
wheezing 3
functional recovery 3
seizures 3
ataxia 2
agitation 2
anorexia 2
oliguria 2
syncope 2
hypothermia 2
chest pain 1
nasal congestion 1
tremor 1
chest tightness 1
Welt 1
bloating 1
epigastric distress 1
cyanosis 1
clubbing 1
skin damage 1
dizziness 1
generalized abdominal pain 1
generalized rash 1
persistent cough 1
pallor 1
belching 1
analgesia 1
pelvic pain 1
hemiplegia 1
skin irritation 1
Wind 1
acute abdomen 1
Drug
CSF 1265
IL-2 338
IFN-gamma 224
G-CSF 177
Dermatol 56
IL-11 34
Leukine 30
p75 22
IFN-beta 20
CTX 17
IL-1ra 16
Filgrastim 14
Filgrastim 14
Asthma 12
lysine 11
Histamine 11
LCM 11
LCM 11
CTX 9
G418 9
Gel 9
CTX 9
DNase I 9
Leaf 8
AZT 7
CCL 7
Indomethacin 7
AZT 7
Hypaque 6
Hypaque 6
Novantrone 6
MAP 6
anti-CD33 5
ROS 5
PTH 5
Asn 5
MRC 4
Prednisolone 4
Gleevec 4
Mutagen 4
MDS 4
VCR 4
CAM 4
ABC 4
Budesonide 3
Nephron 3
Ipilimumab 3
Provenge 3
Ethanol 3
TAT 3
Rituximab 3
Taxol 3
Gelatin 3
ETS 3
AraC 3
TEL 3
Allergen 3
Nephron 3
GEO 3
ICI 3
Imatinib 3
Imiquimod 3
Infliximab 2
Heme 2
THF 2
ADM 2
Taxotere 2
Fragmin 2
CPT-11 2
Bifidobacterium 2
Herceptin 2
CTC 2
Vitamin A 2
Norplant 2
Adriamycin 2
Silica 2
Ganciclovir 2
Docetaxel 2
VCR 2
Tacrolimus 2
lactose 2
Sorafenib 2
CTC 2
DEX 2
balanced salt solution 2
Retinoic acid 2
Activin 2
Anagrelide 2
Biopolymers 2
EML 2
Amifostine 2
Infliximab 2
Methylprednisolone 2
Dasatinib 2
SF6 1
CFS 1
Daclizumab 1
Amrinone 1
FLP 1
Dithranol 1
Ethyol 1
Bromelain 1
Intron A 1
Vinorelbine 1
Kenyan 1
TTC 1
Simvastatin 1
Salbutamol 1
Olopatadine hydrochloride 1
Engerix-B 1
THA 1
uPA 1
Epoetin 1
Gelfoam 1
Crotonaldehyde 1
ADR 1
Arsenic trioxide 1
MDM 1
Iloprost 1
Red ginseng 1
KGF 1
Albumin 1
NBT 1
Ciglitazone 1
Campath 1
Fusidic Acid 1
NADH 1
ascorbate 1
Misoprostol 1
Emodin 1
Prednisone 1
Meth 1
PE2 1
TMS 1
NVP 1
ddI 1
Belagenpumatucel-L 1
Aloe 1
Navelbine 1
ROC 1
Ginseng 1
Glutathione 1
MTC 1
Etoposide 1
Ringer's solution 1
Rosiglitazone 1
Nedocromil sodium 1
Pirfenidone 1
Synercid 1
citric acid 1
ALA 1
Aminoguanidine 1
Estrogens 1
Zileuton 1
Adenosine triphosphate 1
NLF 1
Dalteparin 1
Pronase 1
beta-Galactosidase 1
Micafungin 1
more...
Enzyme
mitogen-activated protein kinase 176
ERK 115
protein kinase C 89
focal adhesion kinase 80
peroxidase 72
protein kinase 71
reverse transcriptase 70
MIP 47
MEK 40
phosphatidylinositol 3-kinase 38
luciferase 35
CD13 30
alkaline phosphatase 26
trypsin 26
RNase 24
RNase 23
RNA polymerase 21
thymidine kinase 21
tyrosinase 20
phospholipase C 19
catalase 19
lipoxygenase 19
caspase-3 19
superoxide dismutase 18
NADPH oxidase 17
NADPH oxidase 17
lactate dehydrogenase 15
lysozyme 15
transcriptase 15
arginase 14
beta-galactosidase 14
phospholipase A2 14
glutathione S-transferase 13
thrombin 12
CD10 12
collagenase 12
prostate-specific antigen 11
elastase 10
chloramphenicol acetyltransferase 10
phosphodiesterase 10
calcineurin 10
IKK 9
tryptase 9
caspase-8 9
neuraminidase 9
proteasome 9
granzyme B 9
thyroid peroxidase 9
phospholipase D 8
APC 8
neutrophil elastase 8
NO synthase 8
BAL 8
urokinase-type plasminogen activator 8
P-glycoprotein 7
alanine aminotransferase 7
S1 nuclease 7
ATPase 6
ribonuclease 6
MAP 6
aspartate aminotransferase 6
Thy1 6
ribonuclease 6
p80 6
acid phosphatase 6
glutathione peroxidase 6
adenylate cyclase 6
caspase-1 5
PTPase 5
hexosaminidase 5
beta-glucuronidase 5
PDE 5
aldehyde dehydrogenase 5
BMT 5
PARP 4
AMPK 4
CDR 4
indoleamine 2,3-dioxygenase 4
firefly luciferase 4
phosphoinositide 3-kinase 4
PAM 4
guanylate cyclase 4
deoxycytidine kinase 4
tissue plasminogen activator 4
PNGase F 4
creatine kinase 4
DCF 4
cytosine deaminase 3
TAT 3
acetylcholinesterase 3
glyceraldehyde-3-phosphate dehydrogenase 3
matrix metalloproteinase 9 3
chymase 3
MDP 3
ornithine decarboxylase 3
cdc2 3
p100 3
matrix metalloproteinase 2 3
proteinase K 3
choline acetyltransferase 3
phosphoglycerate kinase 3
15-lipoxygenase 3
dihydrofolate reductase 3
farnesyltransferase 3
DNA polymerase 3
farnesyltransferase 3
DNA methyltransferase 2
adenosine deaminase 2
sulfatase 2
adenosine deaminase 2
retinal dehydrogenase 2
diacylglycerol kinase 2
glyceraldehyde-3-phosphate dehydrogenase 2
papain 2
DNase 2
bromelain 2
lipase 2
xanthine oxidase 2
chymotrypsin 2
sialidase 2
glyceraldehyde-3-phosphate dehydrogenase 2
myosin light chain kinase 2
cruzipain 2
transglutaminase 2
MMP-3 2
glucose-6-phosphate dehydrogenase 2
TSA 2
MEKK1 2
ACS 2
GSK 2
AMPK 2
glucocerebrosidase 2
protein phosphatase 2A 2
tyrosine hydroxylase 2
carbonic anhydrase 2
renin 2
histone acetyltransferase 2
prolyl hydroxylase 2
furin 2
TSP-1 2
glyceraldehyde-3-phosphate dehydrogenase 2
glyceraldehyde-3-phosphate dehydrogenase 2
histone demethylase 2
factor C 2
demethylase 2
cathepsin G 2
caspase-9 2
MTD 2
TACE 2
asparaginase 2
phenylalanyl-tRNA synthetase 1
urease 1
carboxypeptidase A 1
matriptase 1
kallikrein 1
deoxycytidine deaminase 1
tissue kallikrein 1
arylsulfatase 1
cytidine deaminase 1
paraoxonase 1
more...
Compound
DNA 493
Dec 476
Clin 374
tyrosine 218
acetate 215
TNF 205
calcium 166
Phe 118
oxygen 96
nitric oxide 79
sodium 77
retinoic acid 69
leucine 57
serine 49
sulfate 47
phosphate 42
cAMP 41
THP 38
methionine 38
THP 38
COS 34
arginine 34
glucose 33
water 30
Dexamethasone 28
PMA 26
PMA 26
Ara-C 25
cysteine 25
MEK 25
hydrogen 24
MTT 24
H2O2 24
fMet 23
Ara-C 23
alanine 23
galactose 23
LTC4 22
PEG 21
threonine 20
His 20
SDS 19
TPA 18
lysine 18
AMP 18
DBA 18
TPA 18
CTX 17
iodine 16
Optimal 16
FMLP 16
DBA 16
DBA 16
DMSO 15
ATP 15
PGE 15
ammonium 15
Interleukin-2 15
HPP 14
DEAE 14
Tyrosine 14
iron 14
tryptophan 14
uridine 14
BCG 14
nitrogen 13
thioglycollate 12
AZT 12
PGE2 12
ethanol 11
ABL 11
Histamine 11
ADP 11
tryptophan 10
Gly 10
vitamin D 10
proline 10
superoxide radical 10
BCR 10
bromide 10
Asp 10
tryptophan 10
neopterin 10
tryptophan 10
cGMP 10
Cycloheximide 9
Cbl 9
CO2 9
VP-16 9
Actinomycin D 9
creatinine 8
MDA 8
GMP 8
NH2 8
salt 8
BAL 8
FK506 8
N-acetylcysteine 7
CMK 7
hyaluronic acid 7
GTP 7
NFS 7
PEG 7
GSH 7
GSH 7
aluminum 7
palmitic acid 6
ADP 6
Hypaque 6
PAM 6
EDTA 6
EDTA 6
CTP 6
Phosphatidylinositol 6
guanidine 6
MAP 6
Indomethacin 6
zinc 6
ADP 6
glutamine 6
silver 6
nickel 6
2-methylpiperazine 5
anthracene 5
Triton X-100 5
25-dihydroxycholecalciferol 5
pyrrolidine 5
hexose 5
butyric acid 5
benzene 5
PAP 5
GM1 5
butyric acid 5
Cereb 5
CAT 5
PAP 5
PAP 5
CAM 5
CAT 5
BAF 5
pyrrolidine 5
MCA 5
MCA 5
nicotinamide 5
PAP 5
BCNU 5
CAT 5
Paclitaxel 4
urea 4
asparagine 4
Neo 4
Prednisolone 4
acetic acid 4
PAM 4
MIA 4
PAM 4
adenylate 4
Genistein 4
CBDCA 4
phenol 4
more...