Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P04141 (
granulocyte-macrophage colony-stimulating factor
)
6,790
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In order to determine whether human
granulocyte-macrophage colony-stimulating factor
(
GM-CSF
) can enhance phagocytosis, neutrophils were combined with Staphylococcus aureus (S aureus), and both the number of bacteria per neutrophil and the percent of neutrophils phagocytizing were assessed in the absence and presence of
GM-CSF
. Exposure to
GM-CSF
did not enable neutrophils to ingest unopsonized bacteria. When bacteria were opsonized with serum, both the number of bacteria per neutrophil and the percent of cells phagocytizing were increased by treatment with
GM-CSF
. Digestion of extracellular organisms by
lysostaphin
was used to substantiate phagocytosis. These results indicate that another effect of
GM-CSF
on the mature neutrophil is the enhancement of phagocytosis.
...
PMID:Granulocyte-macrophage colony-stimulating factor enhances phagocytosis of bacteria by human neutrophils. 348 77
