Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P04141 (
granulocyte-macrophage colony-stimulating factor
)
6,790
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Male albino mice immunodepressed after the injection of dexamethasone (DEX) were inoculated intraperitoneally with the Guajira strain of
Venezuelan equine encephalomyelitis
(
VEE
) virus. Melatonin (MLT) was administered daily, at a dose of 500 micrograms/kg bodyweight, for 3 days before virus inoculation and 10 days after. Serum levels of
granulocyte-macrophage colony-stimulating factor
(
GM-CSF
) and interleukin-2 (IL-2) were determined in all the experimental groups (control, DEX, DEX + MLT, DEX +
VEE
, DEX +
VEE
+ MLT,
VEE
and MLT). At day 6 after the virus inoculation, the survival rate was significantly increased from 0% in group DEX +
VEE
to 32.5% in the group of immunodepressed infected mice treated with MLT (DEX +
VEE
+ MLT). By day 10 a survival rate of 10% was found in group DEX +
VEE
+ MLT and 0% in group
VEE
. No alterations in IL-2 serum levels were observed. MLT increased
GM-CSF
in control and in DEX-treated mice. In the
VEE
virus-infected mice treated with DEX, serum levels of
GM-CSF
increased progressively from day 1 to 5 postinoculation. In contrast, the levels of
GM-CSF
in infected immunodepressed mice treated with MLT decreased significantly from day 1 to 5 postinoculation. At day 5 after viral inoculation, no differences were detected in the cerebral viral titres in groups
VEE
, DEX +
VEE
and DEX + MLT +
VEE
. These results show that MLT does not inhibit
VEE
viral replication in the brain of immunodepressed mice.
...
PMID:Melatonin prolongs survival of immunodepressed mice infected with the Venezuelan equine encephalomyelitis virus. 1135 63
