Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P04040 (Catalase)
 3,577 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The present study investigates the lytic potential of the reactive oxygen species (ROS) which, as previously shown in our laboratory, are generated within the first minutes following the Fc-receptor-mediated interaction between phagocytic cells and anti-T-cell monoclonal-antibody (mAb)-coated T lymphocytes. A comparative study of ROS production (measured by chemiluminescence (CL] and the cytotoxic effect (evaluated in a 51Cr release antibody-dependent cellular cytotoxicity (ADCC) assay) of human polymorphonuclear (PMN) and mononuclear (MN) cells against mAb-coated autologous, allogeneic and xenogeneic (murine) thymocytes showed that the two reactions were closely interdependent for PMN and co-existed without significant correlation for MN cells. Catalase and superoxide dismutase did not modify ADCC results, suggesting that these ROS scavengers could not diffuse into the target cell destruction area. Colchicine treatment of PMN and MN cells at a dose inhibiting phagocytosis consistently impaired their CL generation and, in parallel, strongly reduced PMN-mediated ADCC but only weakly reduced that of MN cells. PMN and MN cells from 14 patients with chronic granulomatous disease (CGD) were not capable of producing CL after contact with mAb-coated T cells and showed significantly reduced ADCC activities, while PMN and MN cells from mothers carrying the X-linked type of CGD exhibited ADCC and oxidative responses of an intermediate level. We conclude that ADCC mediated by human PMN cells against T cells is mainly dependent upon the generation of ROS, whereas that induced by MN cells is most likely effected by both oxidative and non-oxidative events.
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PMID:Role of oxygen-dependent mechanisms in monoclonal antibody-induced lysis of normal T cells by phagocytes. I.--Human Phagocytes. 387 89

Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by defects of nicotinamide adenine dinucleotide phosphate oxidase. Catalase-positive bacteria and fungi are phagocytosed, but persist within phagocytes, resulting in granulomatous inflammation. Although allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for CGD, HSCT sometimes leads to fatal outcomes related to the exacerbation of persistent infectious or post-infectious inflammatory diseases, particularly in adolescent and young adult patients with a history of recurrent infections and/or multiple granulomas in organs. Here, we present the case of a young adult with X-linked CGD in whom multiple lesions were found in lungs and lymph nodes on both computed tomography and positron emission tomography (PET) scans before allogeneic HSCT, but all the lesions disappeared only on PET scan 5 months after HSCT. Monitoring the activity of multiple pre-existing lesions with PET scan may be beneficial to adolescent and young adult CGD-patients undergoing allogeneic HSCT.
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PMID:Dramatic Improvement in the Multifocal Positron Emission Tomography Findings of a Young Adult with Chronic Granulomatous Disease Following Allogeneic Hematopoietic Stem Cell Transplantation. 2536 70