Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P04040 (Catalase)
 3,577 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The incidence of Streptococcus mutans in dental plaque and the relationship between dental caries and the levels of serum Igs and IgAS was investigated in allergic children. The relationship between IgAS mean levels and a) cariogenic diet, b) fluoride concentration in consumption water and c) different frequency in brush-washing was also studied. Direct examination of specimens obtained from either dental plaque or caries was performed. Cultures in tryptone soy agar and blood agar base were carried out. Catalase and nitrate reductase tests and biochemical tests for the identification of Streptococcus mutans were also done. Seric Igs and IgAS from saliva secretion were measured by radial immunodiffusion technique. Streptococcus mutans were found in 25/45 samples from allergic children, in 3/16 non allergic, in 25/43 children with caries and 3/18 children without caries. IgM reached higher levels in children with caries. Seric IgA average levels were lower in allergic children and were significantly increased in the non-allergic with caries. Most allergic children with caries showed very low IgAS values. Cariogenic diet, fluoride water ingestion and frequent brush-washing had no effect on IgAS concentration. Allergic children with caries showed low levels of seric IgA and Streptococcus mutans were frequently found in dental plaque. In these patients the specific class IgA response against the potentially cariogenic microorganisms was diminished. Allergic as well as non-allergic children with dental caries showed low IgAS levels suggesting that this may be an important factor in caries development.
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PMID:[Incidence of Streptococcus mutans and changes in the concentration of serum immunoglobulins and SIgA in allergic children with caries]. 181 75

Normal human neutrophils triggered by secretory IgA (sIgA) displayed low levels of cytotoxicity towards non-sensitized red blood cells. Catalase completely impaired this non-specific cytotoxicity (NSC), while superoxide dismutase (SOD) significantly enhanced it, suggesting a key role for hydrogen peroxide (H2O2) in the lysis of target cells. Three heme-enzyme inhibitors, sodium azide, sodium cyanide and 3-amino-1,2,4-triazole, did not decrease NSC, but significantly enhanced it, suggesting that the mechanism involved is not dependent upon myeloperoxidase (MPO). Heat-aggregated IgG (HA-IgG) synergize with sIgA in promoting NSC. It was also found that gamma interferon significantly enhanced neutrophil-mediated NSC induced by sIgA, its effect being more dramatic on NSC triggered by low concentrations of sIgA. The significance of these results is discussed.
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PMID:Neutrophil-mediated cytotoxicity induced by secretory IgA. 216 28

inhalation of benzene vapours promote various and dangerous health problems. Fuel station workers are most susceptible to benzene inhalation toxicity. Samples were collected twice, at beginning of the study and 6 months later from 40 fuel station workers from different egyptian governorates and 10 control healthy volunteers. Fuel station workers were sub divided into four groups according to years working in the station. All of them are exposed to benzene vapours and exhausts during their duties, their work shifts were 8 hrs./day. Results indicated that; benzene vapours exposure induced significant increasing in serum Lead and Cadmium and Myeloperoxidase (MPO) enzyme activity levels. This goes with marked immunologic changes presented by decreases in immunoglobulins; IgA and IgG, along with increases in levels of IgM and IgE. Also, Malondialdehyde (MDA) levels were significantly increased. Meanwhile, reduction in some other biochemical parameters including; Copper, Zinc and Iron micronutrients, as well as; Superoxide Dismutase (SOD), Catalase (CAT) enzyme levels and Glutathione (GSH) content. Hence, the study inferred that prolonged benzene inhalation can lead to biochemical and immune disorders, probably through potentiating oxidative stress and inflammation pathways.
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PMID:Biochemical study on occupational inhalation of benzene vapours in petrol station. 3100 48