Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Enzyme
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Query: UNIPROT:P04040 (
Catalase
)
3,577
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Campylobacter concisus
is an emerging enteric pathogen that is associated with inflammatory bowel disease. Previous studies demonstrated that
C. concisus
is non-saccharolytic and hydrogen gas (H
2
) is a critical factor for
C. concisus
growth. In order to understand the molecular basis of the non-saccharolytic and H
2
-dependent nature of
C. concisus
growth, in this study we examined the pathways involving energy metabolism and oxidative stress defence in
C. concisus
. Bioinformatic analysis of
C. concisus
genomes in comparison with the well-studied enteric pathogen
Campylobacter jejuni
was performed. This study found that
C. concisus
lacks a number of key enzymes in glycolysis, including glucokinase and phosphofructokinase, and the oxidative pentose phosphate pathway.
C. concisus
has an incomplete tricarboxylic acid cycle, with no identifiable succinyl-CoA synthase or
fumarate hydratase
.
C. concisus
was inferred to use fewer amino acids and have fewer candidate substrates as electron donors and acceptors compared to
C. jejuni
. The addition of DMSO or fumarate to media resulted in significantly increased growth of
C. concisus
in the presence of H
2
as an electron donor, demonstrating that both can be used as electron acceptors.
Catalase
, an essential enzyme for oxidative stress defence in
C. jejuni
, and various nitrosative stress enzymes, were not found in the
C. concisus
genome. Overall,
C. concisus
is inferred to have a non-saccharolytic metabolism in which H
2
is central to energy conservation, and a narrow selection of carboxylic acids and amino acids can be utilised as organic substrates. In conclusion, this study provides a molecular basis for the non-saccharolytic and hydrogen-dependent nature of
C. concisus
energy metabolism pathways, which provides insights into the growth requirements and pathogenicity of this species.
...
PMID:Analyses of energy metabolism and stress defence provide insights into
Campylobacter concisus
growth and pathogenicity. 3216 25
