Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P04040 (Catalase)
 3,577 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The influence of age on liver gene expression was investigated in two strains of H-2 congenic mice. In B10.RIII mice (H-2r), basal P1- and P3-450 RNA levels progressively decreased 65 and 95%, respectively, between 4 and 28 months of age (P less than or equal to 0.05). Polyaromatic hydrocarbon (PAH) induced P1- and P3-450 RNA levels decreased about 50% during this time (P less than or equal to 0.05). In contrast, in C57BL/10 mice (H-2b) little or no change was detected in basal or induced P1- or P3-450 RNA levels. CuZn-superoxide dismutase RNA decreased 80 to 90% between 4 and 9 months of age in B10.RIII mice, while a quantitatively smaller decrease of 50 to 65% was found in C57BL/10 mice (P less than or equal to 0.05). Catalase RNA decreased approximately 80% between 4 and 9 months of age in B10.RIII mice, and a similar decrease was found in C57BL/10 mice. Down regulation of these genes may explain the reduced activities of the cognate hepatic enzymes, and reduced xenobiotic metabolism found in older animals.
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PMID:Age-related down regulation of hepatic cytochrome P1-450, P3-450, catalase and CuZn-superoxide dismutase RNA. 169 20

The influence of age and life-span-prolonging caloric restriction on the expression of hepatic genes for xenobiotic and activated oxygen metabolism was investigated in female C3B10RF1 mice, a long-lived hybrid strain. Animals were fed either ad libitum, or diets reduced 20% or 52% in total calories but approximately unchanged in total protein, vitamins, and minerals. Cytochrome P1- and P3-450 (cyp1A1 and cyp1A2, respectively) mRNA levels decreased approximately 40% between age 4-5 months (young) and 30-31 months (old) in ad libitum fed animals (p less than or equal to .05). Caloric restriction eliminated this decrease. Manganese-superoxide dismutase mRNA decreased significantly in old ad libitum fed mice, and caloric restriction eliminated this decrease. No change in manganese-superoxide dismutase activity was detected, probably due to its low level and the large variability inherent in the assay. Catalase mRNA increased with age, but was not affected by diet. Catalase activity increased significantly with caloric restriction in young and old mice, in the absence of an increase in catalase mRNA, suggesting translational or posttranslational effects. CuZn-superoxide dismutase, glutathione peroxidase and epoxide hydrolase mRNA, and the ratio of ribosomal to total mRNA did not change with age or diet.
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PMID:Influence of age and caloric restriction on expression of hepatic genes for xenobiotic and oxygen metabolizing enzymes in the mouse. 203 Feb 68