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Symptom
Drug
Enzyme
Compound
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Gene/Protein
Disease
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Compound
Target Concepts:
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Enzyme
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Query: UNIPROT:P04040 (
Catalase
)
3,577
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In this paper, the quenching of hydrogen peroxide by catalase, sodium hypochlorite, sodium thiosulfate and sodium sulfite, prior to UFC testing, was investigated. Sodium hypochlorite, sodium thiosulfate and sodium sulfite were found to be unsuitable for quenching H2O2 residuals because the procedures are time-consuming and complicated in that they require potentially multiple measurements of the peroxide and chlorine residuals. In contrast, quenching of peroxide with catalase is a simple procedure.
Catalase
doses of less than 0.2 mg/L were found to have no impact on
DBP
(TTHM, HAA and aldehyde) formation in the UFC test, and the time that was needed to quench 100 mg/L peroxide (room temperature, pH 8.3) was less than 10 min. In addition, peroxide was found to react with DPD reagents that are used to measure chlorine residuals, a phenomenon that may lead to falsely high chlorine residuals in the UFC test.
...
PMID:Optimal methods for quenching H2O2 residuals prior to UFC testing. 1286 37
This study compared the effects of di(n-butyl) phthalate (
DBP
) on the oxidative damage and antioxidant enzymes activity in testes of hyperthyroid rats. Hyperthyroidism was induced in pubertal male rats by intraperitoneal injection of triiodothyronine (T3, 10 microg/kg body weight) for 30 days. An oral dose of
DBP
(750 mg/kg) was administered simultaneously to normal or hyperthyroid (T3) rats over a 30-day period. No changes in body weight were observed in the hyperthyroid groups (T3, T3 +
DBP
) compared with controls. There were significantly higher serum T3 levels observed in the hyperthyroid rats than in the control, but the serum thyroid stimulating hormone levels were markedly lower in the hyperthyroid rats.
DBP
significantly decreased the weight of the testes in the normal (
DBP
) and hyperthyroid (T3 +
DBP
) groups. The serum testosterone concentrations were significantly lower in only
DBP
group.
DBP
significantly increased the 8-hydroxy-2-deoxyguanosine (8-OHdG) level in the testes, whereas the
DBP
-induced 8-OHdG levels were slightly higher in T3 +
DBP
group. Superoxide dismutase and glutathione peroxidase activities were significantly higher in the testes of the
DBP
or T3 +
DBP
groups.
Catalase
(
CAT
) activity was significantly higher in the
DBP
treatment group, but the T3 +
DBP
group showed slightly lower
DBP
-induced
CAT
activity. The testicular expression of thyroid hormone receptor alpha-1 (TRalpha-1) was significantly higher in the
DBP
groups, and androgen receptor (AR) expression was not detected in the
DBP
treatment group. In addition,
DBP
significantly increased the peroxisome proliferator-activated receptor-r (PPAR-r) levels in the testis. These results suggest that hyperthyroidism can cause a change in the expression level of PPAR-r in testes, and may increase the levels of oxidative damage induced by the metabolic activation of
DBP
.
...
PMID:Effect of di(n-butyl) phthalate on testicular oxidative damage and antioxidant enzymes in hyperthyroid rats. 1749 41
Dibutyl phthalate
(
DBP
) poses a severe threat to aquatic ecosystems, introducing hazards to both aquatic species and human health. The ecotoxic effects of
DBP
on aquatic organisms have not been fully investigated. This study investigates acute toxicity, oxidative damage, and antioxidant enzyme parameters in neonate and adult
Daphnia magna
exposed to
DBP
. The obtained results show comparable
DBP
toxic responses in neonates and adults. The median lethal concentrations (LC
50
) of
DBP
in neonates exposed for 24 and 48 h were 3.48 and 2.83 mg/L, respectively. The LC
50
of adults for the same
DBP
exposure durations were 4.92 and 4.31 mg/L, respectively. Increased hydrogen peroxide and malondialdehyde were found in neonates and adults at both 24 and 48 h, while the total antioxidant capacity decreased. Superoxide dismutase activity increased significantly in neonates and adults exposed to 0.5 mg/L
DBP
, and subsequently diminished at higher
DBP
concentrations and prolonged exposure.
Catalase
and glutathione S-transferases activities both decreased markedly in neonates and adults. The changes observed were found to be time and concentration dependent. Overall, these data indicated that the acute toxic effects of
DBP
exposure on neonates were more pronounced than in adults, and oxidative injury may be the main mechanism of
DBP
toxicity. These results provide a functional link for lipid peroxidation, antioxidant capacity, and antioxidant enzyme levels in the
Daphnia magna
response to
DBP
exposure.
...
PMID:Acute toxicity and responses of antioxidant systems to dibutyl phthalate in neonate and adult
Daphnia magna
. 3088 75
