Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P04040 (
Catalase
)
3,577
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Pyrroloquinoline quinone
(
PQQ
) plays a role as a vitamin or growth factor. Low concentrations of
PQQ
induced DNA cleavage sites frequently at thymine and cytosine residues in the presence of NADH and Cu(II).
Catalase
and bathocuproine inhibited DNA damage, whereas free hydroxyl radical scavengers did not. Electron spin resonance and UV-visible spectrometries showed generation of semiquinone radical and superoxide during the reaction of
PQQ
with NADH. These results suggest that NADH-dependent
PQQ
redox cycle generated superoxide and hydrogen peroxide to mediate copper-dependent DNA damage. The present study has proposed a requirement to investigate the potentiality of
PQQ
carcinogenicity.
...
PMID:NADH-mediated DNA damage induced by a new coenzyme, pyrroloquinoline quinone, in the presence of copper(II) ion. 881 12
