Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P04040 (Catalase)
 3,577 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mycobacterium phlei contains two catalase activities and a single peroxidase activity. The latter is associated with one of the catalases. The single catalase-peroxidase enzyme accounted for 75% of the total catalase activity and was lost upon acquisition of resistance to the antitubercular drug isoniazid (INH). Heat-treated (68 degrees C) wild-type cells showed similar decreases in catalase activity as well as complete loss of peroxidase activity. Catalase activity in the INH-resistant strain of M. phlei (Inh(r)) was unaffected by heating. The heat-sensitive catalase of the wild-type M. phlei was completely inhibited by 0.1 M INH, and Cu(2+) enhanced this inhibitory effect by 100-fold. No inhibition of activity was found with the heat-stable enzyme. Equivalent inhibition of catalase was also observed with nicotinic acid hydrazide and benzoic acid hydrazide. Peroxidase activity was also completely inhibited by any one of the three hydrazides, either INH, benzoic acid hydrazide, or nicotinic acid hydrazide at 10(-3) M. The presence of two catalase activities and the loss of one (catalase-peroxidase) on acquiring INH resistance or heating wild-type cells was confirmed by acrylamide gel electrophoresis of the cell-free extracts.
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PMID:Differentiation of catalases in Mycobacterium phlei on the basis of susceptibility to isoniazid: association with peroxidase and acquired resistance to isoniazid. 92 Dec 49

A case of cutaneous atypical mycobacteriosis due to Mycobacterium (M.) kansasii is reported. A 41-year-old man, who had lived in Kawasaki city, was seen in April 1988 because of sores on the dorsum of left forefinger which had been present for one month. Physical examination revealed an erythematous, edematous plaque approximately 2 and 4 cm overlying proximal and middle phalanx of left index finger. Otherwise his physical findings were normal. Laboratory studies including X-ray examinations of the chest and left hand were normal. The histopathology revealed a mixed cellular infiltration consists of mononuclear cells and neutrophils with necrosis in the dermis. No granuloma formation was observed. In the deep dermis, some acid fast bacilli (AFB) were demonstrated. The culture for AFB was positive with the following characteristics: Acidfastness (+), Niacin (-), Photochromogenecity (+), Growth at 37 degrees C (+), at 42 degrees C (+), at 45 degrees C (-), Nitrate reduction (+), Catalase (+). These tests were diagnostic of Group I photochromogen, M. kansasii. We reviewed 19 cases of cutaneous atypical mycobacteriosis due to M. kansasii in the world literature including our case and found that there were three types of the disease: (1) Cutaneous chronic granulomatous type, (2) Disseminated acute pyogenic type and (3) Cutaneous pyogenic type.
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PMID:[Cutaneous atypical mycobacteriosis due to Mycobacterium kansasii--a case report and a review of the literature]. 221 38