Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P04040 (
Catalase
)
3,577
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Extracts of Phellinus linteus (
EPB
), grown on germinated brown rice, protected rats from liver injury induced by carbon tetrachloride (CCl4). Peroxidation products in the liver were decreased to 10% by
EPB
.
Catalase
and superoxide dismutase activities were significantly decreased to 55% and 39% by CCl4 administration, but
EPB
blocked this effect, resulting in enzyme activities at control levels. Expression of cytochromeP450 2E1 (CYP2E1) protein was significantly decreased to 88% in CCl4-treated rats but remained at control levels when
EPB
was also administered.
EPB
did not affect the altered fatty acid composition induced by CCl4. The hepatoprotective effect of
EPB
may be mediated by
EPB
's prevention of CCl4-induced CYP2E1 degradation.
...
PMID:Extracts of Phellinus linteus grown on germinated brown rice suppress liver damage induced by carbon tetrachloride in rats. 1496 15
