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Query: UNIPROT:P04040 (Catalase)
 3,577 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. Hyperbaric (HBO(2)) and topical oxygen represent two accepted options to oxygenate tissues. The aim of the present study was to investigate the effect of HBO(2) on energy metabolism and anti-oxidant enzymes in a rat model of ischaemia-reperfusion (IR) skeletal muscle injury. 2. In the first study, 16 rats were randomized to a HBO(2)-treated group (Group 1; n = 8) and an untreated group (Group 2; n = 8). Under general anaesthesia, right hind limb ischaemia was produced by application of a rubber-band tourniquet for 3 h. After 2 h ischaemia, Group 1 rats received HBO(2) during the last hour of ischaemia. The HBO(2) consisted of 100% oxygen delivered at 282.8 kPa absolute pressure. Group 2 rats were not treated. Following the ischaemic period, the tourniquet was released for 1 h. A microdialysis probe was used to sample lactate, glucose and glycerol concentrations in the muscle extracellular tissue every 15 min throughout each experiment. 3. In the second study, 24 rats were randomized into four groups (n = 6 each). The first two groups were subjected to the IR injury protocol outlined above and either treated (Group 1) or untreated (Group 2) with HBO(2). Group 3 rats were anaesthetized, did not undergo IR injury, but underwent HBO(2) treatment. Group 4 rats were anaesthetized but did not undergo either IR injury or HBO(2) treatment. At end of each experiment, the biceps femoris muscle was removed and assayed for superoxide dismutase (SOD) and catalase (CAT) activity. Malondialdehyde (MDA) was measured to estimate the extent of membrane lipid peroxidation. 4. Three hours of skeletal muscle ischaemia resulted in a gradual decrease in the glucose concentration and a gradual increase in the lactate concentration within the extracellular fluid of the affected skeletal muscle tissue. Treatment with HBO(2) had no effect on the glucose concentration; however, HBO(2) significantly attenuated the ischaemia-induced increase in lactate and glycerol. In both groups, glucose concentration increased rapidly during reperfusion; glucose concentration returned to pre-ischaemic levels 15 min after reperfusion both with and without HBO(2). 5. Catalase activity and MDA increased significantly after 1 h of reperfusion. The HBO(2) attenuated the reperfusion-induced increase in CAT activity and MDA. 6. The results of the study suggest that HBO(2) may have some beneficial effect by decreasing lactate and glycerol levels and modulating anti-oxidant enzyme activity in postischaemic skeletal muscle in our rat model of tourniquet-induced IR skeletal muscle injury.
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PMID:Effects of hyperbaric oxygen on glucose, lactate, glycerol and anti-oxidant enzymes in the skeletal muscle of rats during ischaemia and reperfusion. 1720 38

This study was carried out to investigate smoke-induced structural and biochemical changes and protective effects of co-administered melatonin and vitamin C in the kidney. Twenty-four Wistar adult female rats were used in this study. Animals were divided into four groups. The first group rats were used as control. The second group of rats inhaled cigarette smoke. Smile smoke inhaling third and fourth group rats received melatonin and vitamin C, respectively. At the end of experimental study, kidney tissues and blood samples were taken under ether anesthesia. Tissues were prepared and examined by light microscopy. Malondialdehyde and glutathione levels and catalase activity were determined. By light microscopic observation, a decrease of Bowman space of some renal corpuscles, foamy-like tubules, dilatation and congestion of the peritubuler vessels, and atrophy of the some renal corpuscles were observed in group II. In groups III and IV melatonin and vitamin C relatively protected the kidney tissue against smoke intoxication. Biochemical examination showed that malondialdehyde and glutathione levels and catalase activity in group II were higher than in group I. Melatonin and vitamin C injection to group III and IV caused a decrease in malondialdehyde and glutathione levels. Catalase activity did not change in these groups. We have shown that cigarette smoke inhalation caused structural changes in the kidney. However, melatonin and vitamin C administration produced in some degree protection against smoke-induced damage.
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PMID:Effects of melatonin and vitamin C on cigarette smoke-induced damage in the kidney. 1866 69

Celecoxib is increasingly being used in children with rheumatologic complaints. Although the particular concerns about the safety of the drug, there are only a small number of published studies in children. This study was performed to investigate the effects of celecoxib on oxidative stress and antioxidant enzyme activities as well as celecoxib-induced changes in liver, kidneys and stomach of young rats. Four weeks-old Wistar albino, female rats were used. Celecoxib was given by gavage for 14 days. Control rats received only vehicle. Blood and organs were taken under pentobarbital anesthesia. Plasma malondialdehyde levels were increased by treatment. Catalase activity was increased, while glutathione peroxidase activity was decreased. Superoxide dismutase and glucose-6-phosphate dehydrogenase activities was not changed by treatment. The reduced glutathione content of kidneys were higher, while there was no significant difference in liver content, as compared with controls. Significant changes were observed in serum parameters of rats treated with celecoxib. Histopathological evaluation of organs was done by an experienced pathologist unaware of the treatment. Results of the present study indicated the alterations of oxidant/antioxidant status and histopathological changes in tissues of young rats treated with celecoxib.
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PMID:Effects of celecoxib in young rats: histopathological changes in tissues and alterations of oxidative stress/antioxidant defense system. 2138 Aug 9

Hydrogen peroxide was - and is still - considered toxic for a wide range of living organisms. Oxidative stress occurs when there is an excess of pro-oxidants over antioxidants and it has been implicated in several diseases. Catalase is involved in hydrogen peroxide catabolism and is important in defense against oxidative stress. Acatalasemia means the inherited near-total deficiency of catalase activity, usually in reference to red cell catalase. Acatalasemia was thought at first to be an asymptotic disorder. In the absence of catalase, neither the Japanese, or Hungarian acatalasemics nor acatalasemic mice had significantly increased blood glutathione peroxidase activity. In animal models, catalase deficient tissues show much slower rates of removal of extracellular hydrogen peroxide. In catalase knock-out mice, a decreased hydrogen peroxide removing capacity and increased reactive oxygen species formation were reported. Hydrogen peroxide may cause methemoglobinemia in patients with catalase deficiency. During anesthesia for a Japanese acatalasemic patient the disinfection with hydrogen peroxide solution caused severe methemoglobinemia. Patients with inherited catalase deficiency, who are treated with uric acid oxidase (rasburicase) may experience very high concentrations of hydrogen peroxide and may suffer from methemoglobinemia and hemolysis. The high (18.5%) prevalence of diabetes mellitus in inherited catalase deficient individuals and the earlier (10 years) manifestation of the disease may be attributed to the oxidative damage of oxidant sensitive, insulin producing pancreatic beta-cells. Ninety-seven of 114 acatalasemics had diseases related to oxidative stress and aging. The oxidative stress due to catalase deficiency could contribute to the manifestation of diabetes while for the other diseases it may be one of the factors in their causations. In summary, inherited catalase deficiency is associated with clinical features, pathologic laboratory test results, age and oxidative stress related disorders. Rather than considering it a benign condition, it should be considered as a complicating condition for aging and oxidative stress.
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PMID:Inherited catalase deficiency: is it benign or a factor in various age related disorders? 2402 77