Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P04040 (
Catalase
)
3,577
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Catalase
(
CAT
) and peroxisome proliferator activated receptor-gamma2 (PPARgamma2) are important regulators of oxidative stress and inflammation, and may contribute to the development of rheumatoid arthritis (RA). We investigated the association between
CAT
and PPARgamma2 genotypes and risk and severity of RA using 474 cases and 400 controls. Genotyping for the -262C-->T polymorphism of
CAT
and the Pro12Ala polymorphism of PPARgamma2 was performed by PCR-RFLP analysis. Severity of RA was assessed by the anatomical stage according to
Steinbrocker
, and a Korean language version of a Health Assessment Questionnaire (KHAQ). No association was observed between
CAT
and PPARgamma2 genotypes and risk of RA. Our results suggest that genetic polymorphisms of
CAT
and PPARgamma2 do not play a significant role in the susceptibility to RA among Koreans.
...
PMID:Catalase and PPARgamma2 genotype and risk of rheumatoid arthritis in Koreans. 1598
