Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P04040 (Catalase)
 3,577 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of the research was to study the influence of long-term stress conditions on the rate of lipids' peroxidation (LPO), activity of antioxidant system and energy metabolism in brain, cardiac muscle and lymphocytes under 30-days isolation and diurnal cycle violation. Obtained results prove about the increasing of intensity of LPO in studied tissues under long-term stress conditions. According to the data, in lymphocytes, brain and cardiac muscle it was observed quantitative rising in nitric oxide (NO) concentrations. In junction with this it was changed the intensity of LPO, proved by the increase in quantities of products of this process. In contrast with this it was shown decrease in activity of enzymes of antioxidant system: Superoxiddismutase, Catalase, Glutathionreductase and Glutathionperoxidase, also we've studied activities of mitochondrial enzymes, such as, Succinatdehydrogenase, Creatine Kinase and Aconitase. It was shown that isolation and diurnal cycle disorders represent factors that induce remarkable down regulation of energy metabolism and increasing of oxidative stress pathways. Supposedly influence of stress factors could induce nonreversible processes that could stimulate various neurological, cardio-vascular and immune system pathologies.
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PMID:[Activity of white rat antioxidant system under chronic stress]. 2452 34

Adaptation to continuous normobaric hypoxia (CNH) protects the heart against acute ischemia/reperfusion injury. Recently, we have demonstrated the infarct size-limiting effect of CNH also in hearts of spontaneously hypertensive rats (SHR) and in conplastic SHR-mtBN strain characterized by the selective replacement of the mitochondrial genome of SHR with that of more ischemia-resistant Brown Norway rats. Importantly, cardioprotective effect of CNH was more pronounced in SHR-mtBN than in SHR. Thus, here we aimed to identify candidate genes which may contribute to this difference between the strains. Rats were adapted to CNH (FiO2 0.1) for 3 weeks or kept at room air as normoxic controls. Screening of 45 transcripts was performed in left ventricles using Biomark Chip. Significant differences between the groups were analyzed by univariate analysis (ANOVA) and the genes contributing to the differences between the strains unmasked by CNH were identified by multivariate analyses (PCA, SOM). ANOVA with Bonferroni correction revealed that transcripts differently affected by CNH in SHR and SHR-mtBN belong predominantly to lipid metabolism and antioxidant defense. PCA divided four experimental groups into two main clusters corresponding to chronically hypoxic and normoxic groups, and differences between the strains were more pronounced after CNH. Subsequently, the following 14 candidate transcripts were selected by PCA, and confirmed by SOM analyses, that can contribute to the strain differences in cardioprotective phenotype afforded by CNH: Alkaline ceramidase 2 (Acer2), Fatty acid translocase (Cd36), Aconitase 1 (Aco1), Peroxisome proliferator activated receptor gamma (Pparg), Hemoxygenase 2 (Hmox2), Phospholipase A2 group IIA (Ppla2g2a), Dynamin-related protein (Drp), Protein kinase C epsilon (Pkce), Hexokinase 2 (Hk2), Sphingomyelin synthase 2 (Sgms2), Caspase 3 (Casp3), Mitofussin 1 (Mfn1), Phospholipase A2 group V (Pla2g5), and Catalase (Cat). Our data suggest that the stronger cardioprotective phenotype of conplastic SHR-mtBN strain afforded by CNH is associated with either preventing the drop or increasing the expression of transcripts related to energy metabolism, antioxidant response and mitochondrial dynamics.
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PMID:Cardioprotective Regimen of Adaptation to Chronic Hypoxia Diversely Alters Myocardial Gene Expression in SHR and SHR-mtBN Conplastic Rat Strains. 3072 58